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|a 9781617798122
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|a 10.1007/978-1-61779-812-2
|2 doi
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|a (DE-He213)978-1-61779-812-2
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| 245 |
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|a Immunotoxicity, Immune Dysfunction, and Chronic Disease
|h [electronic resource] /
|c edited by Rodney R. Dietert, Robert W. Luebke.
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| 250 |
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|a 1st ed. 2012.
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| 264 |
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1 |
|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2012.
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| 300 |
|
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|a XVI, 452 p.
|b online resource.
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| 336 |
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|a text
|b txt
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| 490 |
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|a Molecular and Integrative Toxicology,
|x 2168-4219
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| 490 |
1 |
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|a Springer eBook Collection
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| 505 |
0 |
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|a Introduction to Immunotoxicity -- The Environment-Immune Route to Chronic Disease -- Asthma and Respiratory Allergies -- Cutaneous Allergies -- Food Allergies -- Factors Involved in Onset of Type1 Diabetes -- Rheumatoid Arthritis -- Environment, Immune Dysfunction and Systemic Lupus Erythematosus -- Multiple Sclerosis, Alzheimer’s Disease and Inflammation: A Hypothetical View -- Immune Dysfunction in Autism Spectrum Disorders -- Atherosclerosis and Inflammatory Heart Disease -- Inflammatory Bowel Disease and Celiac Disease: Environmental Risks Factors and Consequences -- COPD and Other Inflammatory Diseases of the Lung: Focus on AhR signaling -- Environment, the Immune System, and Depression: An Integrative Review and Discussion of the Infection-Defense Hypothesis -- Cancer – Childhood Acute Leukemia -- Environmental Toxicants and Susceptibility to Infection -- Reducing the Prevalence of Immune-Based Chronic Disease.
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| 520 |
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|a Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes,multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus. Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction. Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions. This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students. .
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| 590 |
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|a Loaded electronically.
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| 590 |
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|a Electronic access restricted to members of the Holy Cross Community.
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| 650 |
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|a Pharmacology.
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| 650 |
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0 |
|a Immunology.
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| 650 |
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0 |
|a Molecular biology.
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| 690 |
|
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|a Electronic resources (E-books)
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| 700 |
1 |
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|a Dietert, Rodney R.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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| 700 |
1 |
|
|a Luebke, Robert W.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 830 |
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|a Molecular and Integrative Toxicology,
|x 2168-4219
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| 830 |
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|a Springer eBook Collection.
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| 856 |
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|u https://holycross.idm.oclc.org/login?auth=cas&url=https://doi.org/10.1007/978-1-61779-812-2
|3 Click to view e-book
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