Transforming Growth Factor-Beta in Cancer Therapy, Volume I Basic and Clinical Biology

Transforming Growth Factor-Beta in Cancer Therapy, Volume I Basic and Clinical Biology / edited by Sonia B. Jakowlew.

Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. Part I presents basic concepts of trans...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Jakowlew, Sonia B. (Editor)
Format: eBook
Language:English
Published: Totowa, NJ : Humana Press : Imprint: Humana, 2008.
Edition:1st ed. 2008.
Series:Cancer Drug Discovery and Development,
Springer eBook Collection.
Subjects:
Oncology  .
Cell biology.
Cancer research.
Pharmacology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Basic Concepts of TGF-? Signaling in Normal Physiology and Cancer Pathobiology
  • Component Hardware for Transforming Growth Factor-? Signal Transduction: TGF-? Ligands, TGF-? Receptors, and Smads
  • TGF-? Signaling in Homeostasis and Cancer
  • TGF-? Availability: Latent TGF-? and Latent TGF-? Binding Proteins
  • Biological Functions of Latent TGF-?-Binding Proteins and Activation of TGF-?
  • Regulators of Smad2/3 Transcription and Phosphorylation
  • Interaction of Smad4 and Embryonic Liver Fodrin-?-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression
  • Regulation of Smad Activity by Phosphorylation
  • Nuclear Targeting of TGF-?-Activated Smads in Normal and Tumor Biology
  • Ski, SnoN, and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival
  • Transforming Growth Factor-? in Cancer Therapy: Smurfs in TGF-? Signaling and Regulation of Bone Homeostasis and Cancer
  • Involvement of km23 Dynein Light Chains in TGF ? Signaling
  • TGF-? Signaling in Fibroblastic Cells and Oncogenesis
  • Mechanisms of TGF-?-Induced Apoptosis in Cancer Cells
  • Mechanisms of Cell Cycle Regulation by TGF-? Disabled in Cancer
  • Transforming Growth Factor-? in Cancer Therapy
  • TGF-? and Smad Signaling in Transcriptome Reprogramming During EMT
  • Functional Interactions Between MMPs and TGF-? in Normal and Tumor Tissue
  • Cooperation Between TGF-? and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function
  • Interaction of Oncogenic Ras and TGF?1 Signaling in Cancer: Lessons From the Multistage Skin Carcinogenesis Model
  • TGF-? Superfamily Members in Normal and Tumor Biology
  • Proteomics Analysis of TGF? Superfamily Members
  • Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain Human Cancers
  • Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression
  • Bone Morphogenic Proteins and Angiogenesis in Developing Tumors
  • Histone Methyltransferase and Smad Interactions in BMP Signaling
  • Endoglin (CD105): A Strong Candidate for Immunologic Targeting of Tumor Neovasculature in Human Malignancies
  • Activins and Inhibins in Cancer Progression
  • Bone Morphogenetic Proteins/Growth Differentiation Factors and Smad Activation in Ovarian Granulosa Cells and Carcinoma
  • Regulation of the Transforming Growth Factor-? Superfamily by Betaglycan
  • Uterine Sensitization Associated Gene-1: A Bone Morphogenetic Protein Antagonist with a Role in Kidney
  • Role of Betaig-h3 Gene in Carcinogenesis
  • Activins and the Liver
  • Myostatin Signaling in Normal and Tumor Cells
  • TGF-? in Inflammation and Fibrosis
  • Triterpenoids, Vitamin D, and TGF-?/Smad Signaling in Inflammation and Cancer
  • Thrombospondin-Dependent Activation of Latent TGF-? in Fibrosis and Disease
  • TGF-? in Pulmonary Fibrosis
  • The Role of TGF-? in Bleomycin Induced Pulmonary Fibrosis
  • Smads in the Fibrotic Response: Findings in the Smad3 Knockout Mouse
  • TGF-? Signaling in Renal Fibrosis and Inflammation: Gene Therapy Using Ultrasound-Microbubble-Mediated Inducible Smad7
  • Transforming Growth Factor-? Peptide Signaling in Pulmonary Development, Bronchopulmonary Dysplasia, Fibrosis, and Emphysema
  • The Role of TGF-? in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-? as a Novel Therapeutic Strategy
  • Negative Regulation of the TGF-? Family Signal Pathway by Inhibitory Smads and Their Involvement in Cancer and Fibrosis
  • TGF-?-Related Antifibrotic Strategies in the Eye
  • Transforming Growth Factor-? in Cutaneous Tissue Repair
  • Topical Application of TGF-?1 Peptide Inhibitors for the Therapy of Skin Fibrosis
  • Overexpressed Truncated TGF-? Type II Receptor Inhibits Fibrotic Behavior of Keloid Fibroblasts In Vitro and Experimental Scar Formation In Vivo.

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