Store-Operated Ca²⁺ Entry (SOCE) Pathways Emerging Signaling Concepts in Human (Patho)physiology

Store-Operated Ca²⁺ Entry (SOCE) Pathways Emerging Signaling Concepts in Human (Patho)physiology / edited by Klaus Groschner, Wolfgang F. Graier, Christoph Romanin.

This second edition of the book on Store-operated Ca2+  Entry Pathways has been updated with the newest discoveries that emerged in the field within the last five years. The crystal structure of the Ca2+ signaling core complex is described which adds to a new understanding of the molecular interacti...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Groschner, Klaus (Editor), Graier, Wolfgang F. (Editor), Romanin, Christoph (Editor)
Format: eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
Edition:2nd ed. 2017.
Series:Advances in Experimental Medicine and Biology, 993
Springer eBook Collection.
Subjects:
Cell biology.
Medical biochemistry.
Biophysics.
Biological physics.
Cardiology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Part 1. SOCE - Fundamental Mechanistic Concepts
  • 1. Introduction
  • 2. STIM/Orai Structures: Isolated and in Complex
  • 3. Orai, the Pore-Forming Subunit of the CRAC Channel
  • 4. The Interactions between STIM and Orai
  • 5. Conformational Coupling between STIM and Orai in the Activation of Store-operated Ca2+ Entry
  • 6. Regulation of STIM and Orai by Thiol Modifications
  • 7. Light-operated Ca2+ entry Through Engineered CRAC Channels
  • 8. Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes
  • 9. Contribution of TRPC1 in Store-operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function
  • 10. Auxiliary Proteins of the STIM/Orai Complex
  • Part 2.SOCE - Crosstalk between Organelle and Cellular Compartments
  • 11. Introduction
  • 12. The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE
  • 13.TRPC Proteins as a Link between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores
  • 14. The Role of Mitochondria in the Activation/Maintenance of SOCE Store-operated Ca2+ Entry and Mitochondria
  • 15. The Role of Mitochondria in the Activation/Maintenance of SOCE Membrane Contact Sites as Signaling Hubs Sustaining Store-operated Ca2+ Entry
  •  16.The Role of Mitochondria in the Activation/Maintenance of SOCE - The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility and Location to Store-operated Ca2+ Entry
  • 17.Tissue specificity - The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling
  • 18. Tissue specificity SOCE – Implications for Ca2+ Handling in Endothelial Cells
  • 19. Tissue specificity - Store-operated Ca2+ Entry in Cardiac Myocytes
  • Part  3. SOCE - Molecular and Cellular (Patho) Physiology
  • 20. Introduction
  • 21. Immunological Disorders - Regulation of Ca2+ Signaling in T Lymphocytes
  • 22. Cardiovascular and Hemostatic Discorders Role of STIM and Orai Proteins in Vascular Disorders
  • 23. Cardiovascular and Hemostatic Discorders SOCE and Ca2+ Handling in Platelet Dysfunction
  • 24. Cardiovascular and Hemostatic Discorders - SOCE in Cardiovascular Cells – Emerging Targets for Therapeutic Intervention
  • 25. Cardiac Remodelling and Disease - SOCE and TRPC Signaling in Cardiac Pathology
  • 26. Cardiac Remodelling and Disease - Current Understanding of STIM1/Orai1-mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology
  • 27. Neurological and Motor Disorders - Neuronal Store-operated Ca2+ Signaling: An Overview and its Function
  • 28. Neurological and Motor Disorders - TRPC in Skeletal Muscle
  • 29. Fertility - Store-operated Ca2+ Entry in Germ Cells: Role in Egg Activation
  • 30. Metabolic Disorders and Cancer - Hepatocyte Store-operated Ca2+ Channels in Non-alcoholic Fatty Liver Disease
  • 31. Metabolic Disorders and Cancer - Store-operated Ca2+ Entry in Cancer: Focus on IP3R-mediated Ca2+ Release from Intracellular Stores and its Role in Migration and Invasion.

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