Narcolepsy Pathophysiology, Diagnosis, and Treatment / edited by Christian R. Baumann, Claudio L. Bassetti, Thomas E. Scammell.

The field of narcolepsy has developed enormously within the last 10 years. Indeed the understanding of the basics of sleep-wake regulation and the discovery of new neurotransmitter systems (the hypocretins) has boosted research and key findings in the field, providing important insights into how sle...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Baumann, Christian R. (Editor), Bassetti, Claudio L. (Editor), Scammell, Thomas E. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2011.
Edition:1st ed. 2011.
Series:Springer eBook Collection.
Subjects:
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Etiology and genetics of human narcolepsy
  • Narcolepsy: autoimmunity or secondary to infection?
  • Is narcolepsy a neurodegenerative disorder?
  • The roles of hypocretin/orexin in narcolepsy, Parkinson’s disease, and normal behaviour
  • Histamine in narcolepsy and excessive daytime sleepiness
  • Dopaminergic substrates underlying hypersomnia, sleepiness, and REM sleep expression
  • The serotoninergic system in sleep and narcolepsy
  • Sleep homeostasis, adenosine, caffeine, and narcolepsy
  • Prostaglandin D2: an endogenous somnogen
  • The neurobiology of sleep-wake systems: an overview
  • The hypocretins/orexins: master regulators of arousal and hyperarousal
  • Optogenetic probing of hypocretin/orexin regulation of wakefulness
  • Hypocretin/orexin receptor functions in mesopontine systems regulating sleep, arousal and cataplexy
  • Afferent control of the hypocretin/orexin neurons
  • The neural basis of sleepiness in narcoleptic mice
  • Mathematical models of narcolepsy
  • The hypothalamus and its functions
  • The prehistory of orexin/hypocretin and melanin-concentrating hormone neurons of the lateral hypothalamus
  • Metabolic influence on the hypocretin/orexin neurons
  • Endocrine abnormalities in narcolepsy
  • Appetite and obesity
  • Effects of orexin/hypocretin on ventral tegmental area dopamine neurons: an emerging role in addiction
  • Orexin/hypocretin, drug addiction, and narcolepsy
  • Emotional processing in narcolepsy
  • Depression in narcolepsy
  • The clinical features of cataplexy
  • Parasomnias in narcolepsy with cataplexy
  • The motor system and narcolepsy: Periodic leg movements and restless leg syndrome
  • Spectrum of narcolepsy
  • Secondary narcolepsy
  • Posttraumatic narcolepsy
  • The hypocretin/orexin system and sleepiness in Parkinson’s disease
  • Idiopathic hypersomnia
  • Current diagnostic criteria of adult narcolepsy
  • The arguments for standardized diagnostic procedures
  • Fitness to drive in narcolepsy
  • Treatment of narcolepsy
  • Treatment of narcolepsy in the child.