DNA Methylation and Cancer Therapy

DNA Methylation and Cancer Therapy by Moshe Szyf.

NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated b...

Full description

Saved in:
Bibliographic Details
Main Author: Szyf, Moshe (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: New York, NY : Springer US : Imprint: Springer, 2005.
Edition:1st ed. 2005.
Series:Medical Intelligence Unit
Springer eBook Collection.
Subjects:
Cancer research.
Oncology  .
Biotechnology.
Biochemistry.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • DNA Methylation
  • Epigenetic Mechanisms of Gene Regulation
  • DNA Hypo- vs. Hypermethylation in Cancer
  • DNA Methylation in Urological Cancers
  • DNA Methylation in Colorectal Cancer
  • CpG Island Hypermethylation of Tumor Suppressor Genes in Human Cancer
  • The Loss of Methyl Groups in DNA of Tumor Cells and Tissues
  • Identifying Clinicopathological Association of DNA Hypermethylation in Cancers Using CpG Island Microarrays
  • Methylation Analysis in Cancer
  • Regulation of DNA Methyltransferases in Cancer
  • Inhibition of Poly(ADP-Ribosyl)ation Allows DNA Hypermethylation
  • The Role of Active Demethylation in Cancer and Its Therapeutic Potential
  • Purine Analogues and Their Role in Methylation and Cancer Chemotherapy
  • DNA Methyltransferase Inhibitors
  • Preclinical and Clinical Studies on 5-Aza-2?-Deoxycytidine, a Potent Inhibitor of DNA Methylation, in Cancer Therapy
  • Anticancer Gene Therapy by in Vivo DNA Electrotransfer of MBD2 Antisense
  • Epilogue.

Similar Items