Footmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cells

Footmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cells by Katharina Spanel-Borowski.

The cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In...

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Bibliographic Details
Main Author: Spanel-Borowski, Katharina (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2011.
Edition:1st ed. 2011.
Series:Advances in Anatomy, Embryology and Cell Biology, 209
Springer eBook Collection.
Subjects:
Reproductive medicine.
Human physiology.
Immunology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1 Background
  • 1.1 Innate Immunity, Toll-like Receptors (TLR), and Danger Signals 1.2 The Ovary, Tissue Remodelling, and Immune Privilege
  • 1.3 Design
  • 2 Material and Methods
  • 2.1 Cyclic and Superovulated Ovaries from Rats, Hamsters, Rabbits as well as Canine, Bovine and Human Ovaries
  • 2.1.1 Fibrinolytic Activity and Implants on the Chick Chorioallantois Membrane (CAM)
  • 2.1.2 Fixation, Staining and Counting Ovarian Structures
  • 2.2 Cell Culture Subtypes from Follicles Derived from Patients Under in Vitro Fertilization Therapy
  • 2.3 Cell Culture Subtypes from Bovine Corpus Luteum (CL) and Characterization
  • 3 Footmarks of Innate Immunity
  • 3.1 The Complement System as Danger Sensor in General and in the Ovary
  • 3.2 Mild Danger with Mild Response
  • 3.2.1 Implantation of the Ovary into the CAM
  • 3.2.2 Follicular Atresia
  • 3.3 Moderate Danger by Preovulatory Follicle Rupture and Acute Inflammation with Eosinophils
  • 3.3.1 Recruitment of Eosinophils and Substance P-Like Expression
  • 3.4 Severe Danger in Superovulated Ovaries with Intra-Ovarian Oocyte Release and Thrombus Formation
  • 4 Cytokeratin-Positive (CK+) cell as Potential Dendritic Cells
  • 4.1 Dendritic cells, the TLR System in General and in the Ovary
  • 4.2 Localisation of CK+ Cells in the Intact Ovary
  • 4.2.1 Follicles in Foetal and Adult Ovaries
  • 4.2.2 Corpus Luteum
  • 5 Characterization of Isolated CK+ Cells
  • 5.1 CK+ Cells from Preovulatory Follicles with TLR4 Expression
  • 5.2 CK+ Cells from CL in Comparison to CK-Negative (CK-) Cells
  • 5.2.1 Effects of Interferon-gamma on CK+ Cells from the CL Compared to CK- Cells and to Surface Epithelial Cells
  • 5.2.2 Reflections on Quality of the CK+ Type 1 and Similarity with the Type 5
  • 6 Working Hypothesis and Challenges
  • 7 Clinical Perspectives
  • 8 Concluding Summary and Remarks
  • References
  • Subject index.

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