Targeting the Broadly Pathogenic Kynurenine Pathway

Targeting the Broadly Pathogenic Kynurenine Pathway edited by Sandeep Mittal.

This book highlights the known associations between the kynurenine pathway and various disease states and also examines the current state of drug development and clinical trials of compounds known to alter tryptophan metabolism. This book provides a unique bridge between basic mechanistic understand...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Mittal, Sandeep (Editor)
Format: eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
Edition:1st ed. 2015.
Series:Springer eBook Collection.
Subjects:
Enzymology.
Proteins .
Molecular biology.
Cell physiology.
Neurochemistry.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Description
Summary:This book highlights the known associations between the kynurenine pathway and various disease states and also examines the current state of drug development and clinical trials of compounds known to alter tryptophan metabolism. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It explores the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.   This book also:   ·         Combines basic understanding of the role of the kynurenine pathway with translational applications and clinical relevance ·         Explains the role of the kynurenine pathway in various disease states ·         Explores ongoing clinical trials using IDO/TDO inhibitors.
Physical Description:XV, 430 p. 69 illus., 41 illus. in color. online resource.
ISBN:9783319118703
DOI:10.1007/978-3-319-11870-3

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