Cardiac Remodeling Molecular Mechanisms

Cardiac Remodeling Molecular Mechanisms / edited by Bodh I. Jugdutt, Naranjan S. Dhalla.

The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable pu...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Jugdutt, Bodh I. (Editor), Dhalla, Naranjan S. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2013.
Edition:1st ed. 2013.
Series:Advances in Biochemistry in Health and Disease
Springer eBook Collection.
Subjects:
Medical biochemistry.
Human physiology.
Cardiology.
Molecular biology.
Biochemistry.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Part I: Molecular mechanisms of remodeling in pressure and volume overload hypertrophy and ehart failure
  • β-adrenergic receptor signaling pathway in heart failure
  • Remodeling of potassium channels in cardiac hypertrophy
  • Role of gender in Ca2+ cycling and cardiac remodeling due to heart failure
  • The failing heart: is it an inefficient engine or an engine out of fuel?
  • Regulation of cardiac hypertrophic remodeling by the USP15/SLIM1 pathway
  • Role of galectin-3 pathways in the pathogenesis of cardiac remodeling and heart failure
  • A mitochondriocentric pathway to cardiomyocyte necrosis:  an upstream molecular mechanism in myocardial fibrosis
  • The ACE2/Ang (1-7) pathway in cardiac remodeling due to pressure-overload
  • Local actions of natriuretic peptides and nitric oxide in cardiac remodelling: Implications for therapy
  • Modulating G protein-coupled receptors to effect reverse cardiac remodeling
  • Role of inflammation and matrix proteinases in cardiac remodeling following stress and injury
  • Role of chymase in matrix and myocardial remodeling due to mitral regurgitation. Implications for therapy
  • Cardiac remodeling due to aortic regurgitation and mitral regurgitation
  • Reducing oxidative stress and manipulating molecular signaling events using resveratrol as a therapy for pathological cardiac hypertrophy
  • Angiogenesis, arteriogenesis, and mitochondrial dysfunction
  • Part II: Molecular mechanisms of remodeling after myocardial injury and infarction
  • Subcellular remodeling and cardiac dysfunction due to ischemia-reperfusion injury
  • Role of microRNAs in cardiac hypertrophy and post-infarction remodeling
  • Negative regulators of inflammation as endogenous protective mechanisms in post-infarction remodeling
  • TLR-dependent pathways and Akt/mTOR/P70S6K pathways in cardiac remodeling after myocardial infarction
  • The STAT3 pathway and downstream mechanisms in cardiac remodeling: Friend or foe
  • The role of growth differentiation factor 5 in cardiac repair post myocardial infarction
  • Extracellular matrix biomarkers of adverse remodeling after myocardial infarction
  • Oxidative stress in cardiac repair and remodeling: Molecular pathways and therapeutic strategies
  • Role of SPARC in cardiac extracellular matrix remodeling after myocardial infarction
  • Tissue inhibitor of matrix metalloproteinases in the pathogenesis of heart failure syndromes
  • Intracellular matrix remodeling and cardiac function in ischemia-reperfusion injury
  • Aging and markers of adverse remodeling after myocardial infarction
  • Optimizing stem cell therapy for cardiac repair following a myocardial infarction
  • Regulation of fibrosis after myocardial infarction. Implications for ventricular remodeling
  • The ACE2/Ang-(1-7) pathway in cardiac fibroblasts as a potential target for cardiac remodeling.

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