Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering

Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering by Kiyotaka Akabori.

This Thesis in biological physics has two components, describing the use of X-ray scattering techniques to study the structure of two different stacked lipid membrane systems.  The first part focuses on the interaction between a short 11-mer peptide, Tat, which is part of the Tat protein in the HIV-...

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Bibliographic Details
Main Author: Akabori, Kiyotaka (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
Edition:1st ed. 2015.
Series:Springer Theses, Recognizing Outstanding Ph.D. Research,
Springer eBook Collection.
Subjects:
Biophysics.
Biological physics.
Crystallography.
Cell membranes .
Physical chemistry.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Introduction
  • Lipid bilayers
  • Tat peptide
  • Pb¢ ripple phase
  • Structural and Material Perturbations of Lipid Bilayers Due to HIV-1 Tat Peptide
  • Introduction
  • Materials and Methods
  • Analysis of Molecular Dynamics Simulation Data
  • Results
  • Discussion
  • Conclusions
  • Ripple Phase
  • Introduction
  • Materials and Methods
  • LAXS Data Reduction
  • Results for Fhk Form Factors
  • Models to Fit the Fhk and Obtain the Phase Factors
  • Electron Density Profiles and Coarse Grained Bilayer Structure
  • nGIWAXS: Results
  • tWAXS: Results
  • Thin Rod Model
  • Combining WAXS and LAXS Results for the Major Arm
  • Discussion
  • Conclusion
  • Appendices.

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