Translating Molecular Biomarkers into Clinical Assays Techniques and Applications

Translating Molecular Biomarkers into Clinical Assays Techniques and Applications / edited by Russell Weiner, Marian Kelley.

This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Weiner, Russell (Editor), Kelley, Marian (Editor)
Format: eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2016.
Edition:1st ed. 2016.
Series:AAPS Advances in the Pharmaceutical Sciences Series, 21
Springer eBook Collection.
Subjects:
Pharmaceutical technology.
Pharmacy.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Foreword
  • Fit-For-Purpose Validation
  • Biomarkers in Drug Discovery and Development: Pre-Analytical and Analytical Considerations
  • Biomarker Discovery
  • Application of Quantitative Biomeasures in Early Drug Discovery
  • Biomarkers in discovery and preclinical phase during drug development
  • Incorporating clinical biomarkers into clinical trials
  • Perspectives on Tissue Biobanking for Personalized Medicine
  • The role of commercial biomarker assay kits in preclinical and clinical trials kits
  • Quantification of protein biomarkers using liquid chromatography tandem mass spectrometry
  • LC/MS methods for small Molecule biomarkers
  • Cell-based Assays
  • New Technologies for Cellular Analysis
  • Flow cytometry methods for the Clinical Development of Immunomodulatory Biologics
  • Key mass spectrometry techniques used in clinical biomarker research
  • Clinical Genomic Biomarker Assay Development: Technologies and Issues
  • Implementation of Immunohistochemistry assays for clinical trial sample analyses
  • Strategic Approach to Outsourcing Clinical Biomarker Assays through CRO Relationships
  • In situ hybridization (ISH) in Clinical Biomarker Development. .

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