Lentiviral Vectors and Gene Therapy

Lentiviral Vectors and Gene Therapy by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson.

Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolve...

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Bibliographic Details
Main Authors: Escors, David (Author), Breckpot, Karine (Author), Arce, Frederick (Author), Kochan, Grazyna (Author), Stephenson, Holly (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Basel : Springer Basel : Imprint: Springer, 2012.
Edition:1st ed. 2012.
Series:SpringerBriefs in Biochemistry and Molecular Biology,
Springer eBook Collection.
Subjects:
Gene therapy.
Immunology.
Genetic engineering.
Cell biology.
Oncology  .
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1 Introduction to gene therapy.- 1.1 The concept of gene therapy
  • 1.2 Origins of gene therapy
  • 1.3 Gene therapy in the 1970s
  • 1.4 Gene therapy in the 1980s
  • 1.5 The breakthroughs in gene therapy from the 1990s and 2000s
  • 1.6 Current human gene therapy and lentiviral vectors
  • 1.7. Concluding remarks.- 2 Development of retroviral and lentiviral vectors.- 2.1 Retrovirus biology
  • 2.2 Vectors based on γ -retroviruses
  • 2.3 Vectors based on lentiviruses
  • 2.4 Summary and conclusions.- 3 Cell and tissue gene targeting with lentiviral vectors
  • 3.1 Introduction
  • 3.2 Modification of lentivector tropism by pseudotyping (surface targeting)
  • 3.3 Transcriptional targeting
  • 3.4 Post-transcriptional targeting
  • 3.5 Conclusions.-  4 Immunomodulation by genetic modification using lentiviral vectors
  • 4.1 Introduction to genetic immunotherapy
  • 4.2 Lentivector gene therapy for immunization
  • 4.3 Lentivector gene therapy for the treatment of autoimmune disease
  • 4.4 Conclusions
  • 5 Clinical grade lentiviral vectors.- 5.1 Introduction
  • 5.2 Good manufacturing practise guidelines and clinical grade vector preparations
  • 5.3 Scaling-up lentivector production for clinical application
  • 5.4 Purity of clinical grade lentivectors
  • 5.5 Biosafety
  • 5.6 Final considerations and conclusions.- 6 Human gene therapy with retrovirus and lentivirus vectors
  • 6.1 Introduction
  • 6.2 Correction of Severe Combined Immunodeficiency-X1
  • 6.3 Correction of X-linked chronic granulomatous disease
  • 6.4 Correction of X-linked adrenoleukodystrophy
  • 6.5 Correction of b-thalassaemia
  • 6.6 Correction of Wiscott-Aldrich syndrome
  • 6.7 Conclusions and final considerations.

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