Standing operating procedures for developing acute exposure guideline levels for hazardous chemicals

Standing operating procedures for developing acute exposure guideline levels for hazardous chemicals / Subcommittee on Acute Exposure Guideline Levels [and others].

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Bibliographic Details
Corporate Author: National Research Council (U.S.)
Format: eBook
Language:English
Published: Washington ; [England] : National Academy Press, ©2001.
Subjects:
Hazardous substances > Risk assessment > United States.
Chemicals > Physiological effect.
Threshold limit values (Industrial toxicology)
HEALTH & FITNESS > Safety.
Chemicals > Physiological effect
Hazardous substances > Risk assessment
United States
Online Access:Click for online access
Table of Contents:
  • Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals
  • Copyright
  • Preface
  • Contents
  • Introduction
  • REVIEW OF THE NAC DOCUMENT
  • REFERENCES
  • Roster National Advisory Committee for Acute Exposure Guideline Levels (NAC/AEGL Committee) for Hazardous Substances
  • COMMITTEE MEMBERS
  • Past Committee Members
  • Participants from Cooperative Partner Countries
  • Other Participants
  • Oak Ridge National Laboratory Staff
  • AEGL Program Senior Staff
  • Appendix
  • Preface
  • 1. Overview of AEGL Program and NAC/AEGL CommitteeHISTORY
  • PURPOSE AND OBJECTIVES OF THE AEGL PROGRAM AND THE NAC/AEGL COMMITTEE
  • COMMITTEE MEMBERSHIP AND ORGANIZATIONAL STRUCTURE
  • SELECTION OF CHEMICALS FOR AEGL DEVELOPMENT
  • SCIENTIFIC CREDIBILITY OF AEGL VALUES
  • THE AEGL DEVELOPMENT AND PEER-REVIEW PROCESS
  • Stage 1: Draft AEGLs
  • Stage 2: Proposed AEGLs
  • Stage 3: Interim AEGLs
  • Stage 4: Final AEGLs
  • OPERATION OF THE NAC/AEGL COMMITTEE
  • VALUE OF A COLLABORATIVE EFFORT IN THE AEGL PROGRAM
  • APPLICATIONS OF THE AEGL VALUES
  • ""2. Derivation of AEGL Values""""2.1 CHARACTERIZATION OF AEGLS""; ""2.2 EMPIRICAL TOXICOLOGIC ENDPOINTS AND METHODS FOR DETERMINING EXPOSURE CONCENTRATIONS USED TO DERIVE AEGLS 1, 2, AND 3""; ""2.2.1 Selection of the Highest Exposure Level at Which the Effects That Define an AEGL Are Not Observed""; ""2.2.2 Selection of Health-Effect Endpoints for AEGL-1, AEGL-2, and AEGL-3""; ""2.2.2.1 AEGL-1 Endpoints""; ""2.2.2.1.1 No Value Establishedâ€?AEGL-1 Is Close to or Exceeds AEGL-2""; ""2.2.2.1.2 No Value Establishedâ€?Insufficient Data""
  • ""2.2.2.1.3 Highest Experimental Exposure Without an AEGL-1 Effect""""2.2.2.1.4 Effect Level for a Response""; ""2.2.2.2 AEGL-2 Endpoints""; ""2.2.2.2.1 Highest Experimental Exposure Without an AEGL-2 Effect""; ""2.2.2.2.2 Effect Level for a Toxic Response That Was Not Incapacitating or Not Irreversible""; ""2.2.2.2.3 A Fraction of the AEGL-3 Value""; ""2.2.2.3 AEGL-3 Endpoints""; ""2.2.2.3.1 Highest Exposure Level That Does Not Cause Lethalityâ€?Experimentally Observed Threshold (AEGL-3 NOAEL)""
  • ""2.2.2.3.2 Highest Exposure Level That Does Not Cause Lethalityâ€?Estimated Lethality Thresholdâ€?One-Third of the LC50""""2.2.2.3.3 Highest Exposure Level That Does Not Cause Lethalityâ€?Benchmark Exposure Calculation of the 5% and 1% Response""; ""2.2.2.3.4 Effect Level for a Response""; ""2.3 GUIDELINES AND CRITERIA FOR THE SEARCH STRATEGY, EVALUATION, SELECTION, AND DOCUMENTATION OF KEY DATA AND SUPPORTINGâ€?""; ""2.3.1 Search Strategy""; ""2.3.2 Evaluation, Selection, and Documentation of Key and Supporting Data""; ""2.3.3 Elements for Discussion on Data Adequacy and Research Needs""

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