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1 |
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|a Ashcroft, Frances M.
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1 |
0 |
|a Ion channels and disease :
|b channelopathies /
|c Frances M. Ashcroft.
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| 260 |
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|a San Diego :
|b Academic Press,
|c ©2000.
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| 300 |
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|a 1 online resource (xxi, 481 pages) :
|b illustrations (some color)
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| 336 |
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|a text
|b txt
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|a Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype.
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| 505 |
0 |
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|a Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na<sup>+</sup> Channels. -- Voltage-Gated K<sup>+</sup> Channels. -- Ca-Activated K<sup>+</sup> Channels. -- Inward Rectifier K<sup>+</sup> Channels. -- Voltage-Gated Ca<sup>2+</sup> Channels. -- Voltage-Gated Cl<sup>-</sup> Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na<sup>+</sup> Channels. -- Ligand-Gated Ca<sup>2+</sup> Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index.
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| 504 |
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|a Includes bibliographical references (pages 419-464) and index.
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| 588 |
0 |
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|a Print version record.
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| 506 |
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|3 Use copy
|f Restrictions unspecified
|2 star
|5 MiAaHDL
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| 533 |
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|a Electronic reproduction.
|b [Place of publication not identified] :
|c HathiTrust Digital Library,
|d 2010.
|5 MiAaHDL
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| 538 |
|
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|a Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
|u http://purl.oclc.org/DLF/benchrepro0212
|5 MiAaHDL
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| 583 |
1 |
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|a digitized
|c 2010
|h HathiTrust Digital Library
|l committed to preserve
|2 pda
|5 MiAaHDL
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| 650 |
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|a Ion channels.
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| 650 |
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0 |
|a Pathology, Molecular.
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| 650 |
|
7 |
|a MEDICAL
|x Pathology.
|2 bisacsh
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| 650 |
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7 |
|a MEDICAL
|x Pathophysiology.
|2 bisacsh
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| 650 |
|
7 |
|a Ion channels.
|2 blmlsh
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| 650 |
|
7 |
|a Cell control mechanisms.
|2 blmlsh
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| 650 |
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7 |
|a Ion channels
|2 fast
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| 650 |
|
7 |
|a Pathology, Molecular
|2 fast
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| 650 |
|
7 |
|a Chronische Krankheit
|2 gnd
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| 650 |
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7 |
|a Funktionsstörung
|2 gnd
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| 650 |
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7 |
|a Ionenkanal
|2 gnd
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| 650 |
1 |
7 |
|a Kanalopathieën.
|2 gtt
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| 650 |
|
7 |
|a Pathologie moléculaire.
|2 ram
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| 650 |
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7 |
|a Canaux ioniques.
|2 ram
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| 650 |
|
7 |
|a Membrane cellulaire.
|2 ram
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| 758 |
|
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|i has work:
|a Ion channels and disease (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCG9KYhpBQdRphH3BBdQMKd
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
| 776 |
0 |
8 |
|i Print version:
|a Ashcroft, Frances M.
|t Ion channels and disease.
|d San Diego : Academic Press, ©2000
|z 0120653109
|z 9780120653102
|w (DLC) 98085618
|w (OCoLC)42686352
|
| 856 |
4 |
0 |
|u https://ebookcentral.proquest.com/lib/holycrosscollege-ebooks/detail.action?docID=306685
|y Click for online access
|
| 903 |
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|a EBC-AC
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| 994 |
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|a 92
|b HCD
|