Ancestral sequence reconstruction

Ancestral sequence reconstruction / edited by David A. Liberles.

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Bibliographic Details
Other Authors: Liberles, David A. (Editor)
Format: eBook
Language:English
Published: Oxford ; New York : Oxford University Press, 2007.
Subjects:
Nucleotide sequence.
Evolutionary genetics.
SCIENCE > Life Sciences > Molecular Biology.
Evolutionary genetics
Nucleotide sequence
Online Access:Click for online access
Table of Contents:
  • 1. The Early Days of Paleogenomics, Connecting Molecules to the Planet; 2. Ancestral Sequence Reconstruction as a Tool to Understand Natural History and Guide Synthetic Biology: Realizing and Extending the Vision of Zuckerkandl and Pauling; 3. Linking Sequence to Function in Drug Design with Ancestral Sequence Reconstruction; 4. Probabilistic Models and Their Impact on the Accuracy of Reconstructed Ancestral Sequences; 5. Probabilistic Ancestral Sequences Based on the Markovian Model of Evolution- Algorithms and Applications; 6. Estimating the History of Mutations on a Phylogeny; 7. Coarse Projections of the Protein-Mutational Fitness Landscape; 8. Dealing with Uncertainty in Ancestral Sequence Reconstruction: Sampling from the Posterior Distribution; 9. Evolutionary Properties of Sequences and Ancestral State Reconstruction; 10. Reconstructing the Ancestral Eukaryote- Lessons from the Past; 11. Using Ancestral Sequence Inference to Determine the Trend of Functional Divergence After Gene Duplication; 12. Reconstruction of Ancestral Proteomes; 13. Computational Reconstruction of Ancestral Genomic Regions from Evolutionarily Conserved Gene Clusters; 14. Experimental Resurrection of Ancient Biomolecules: Gene Synthesis, Heterologous Protein Expression, and Functional Assays; 15. Dealing with Model Uncertainty in Reconstructing Ancestral Proteins in the Laboratory: Examples from Ancestral Visual Pigments and GFP-like Proteins; 16. Unraveling the Evolution of Complexity by Resurrecting Ancient Genes; 17. A Thermophilic Last Universal Ancestor Inferred from its Estimated Amino Acid Composition; 18. The Resurrection of Ribonucleases from Mammals. From Ecology to Medicine; 19. Evolution of Specificity and Diversity.

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