Towards drugs of the future : key issues in lead finding and lead optimization

Towards drugs of the future : key issues in lead finding and lead optimization / edited by C.G. Kruse and H. Timmerman.

The number of novel medications in the global industry pipeline is insufficient to suffice demand of the markets, the financial performance of several companies is declining, and sales and marketing costs are rising. This title addresses the development in synthetic and medicinal chemistry with the...

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Bibliographic Details
Corporate Authors: Solvay Pharmaceuticals Conference on Medicinal Chemistry Garmisch-Partenkirchen, Germany, Solvay Pharmaceuticals
Other Authors: Kruse, C. G. (Chris G.), 1952-, Timmerman, H. (Hendrick)
Format: eBook
Language:English
Published: Amsterdam : IOS Press, 2008.
Series:Solvay Pharmaceuticals Conferences ; v. 9.
Subjects:
Pharmaceutical chemistry > Congresses.
Drug development > Congresses.
Pharmaceutical industry > Congresses.
MEDICAL > Drug Guides.
MEDICAL > Pharmacology.
BIOGRAPHY & AUTOBIOGRAPHY > Medical.
MEDICAL > Pharmacy.
MEDICAL > Nursing > Pharmacology.
Drug development
Pharmaceutical chemistry
Pharmaceutical industry
Conference papers and proceedings
Online Access:Click for online access
Table of Contents:
  • Title page; Preface; List of Contributors; Contents; Conference Preface and Keynote Lecture; A Thermodynamic Platform for Drug Discovery and Optimization; Structure-Based Design: Past, Present, and Future; Sense and Nonsense in Drug Discovery: A Chemical Perspective; Synthesis at the Interface of Chemistry and Biology: How and Why?; Drug Design with ADME in Mind: Recent Paradigm Shifts in Drug Discovery; Hypothesis Generation for Scientific Discovery. Examples from the Use of KEM®, a Rule-Based Method for Multi-Objective Analysis and Optimization
  • Does Size Matter? Facts and Thoughts on Recombinant DrugsCan Nanotechnology Improve the Oral Delivery of Therapeutic Proteins?; The Omeprazole Story: How Endurance in Research May Pay Off; Conceptual Design of Cannabinoid CB1 Receptor Antagonists; Author Index

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