Human genome epidemiology : building the evidence for using genetic information to improve health and prevent disease

Human genome epidemiology : building the evidence for using genetic information to improve health and prevent disease / edited by Muin J. Khoury [and others].

This text describes the role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It provides a foundation that should help researchers, policy makers and practitioners integrate genomics into medical and public health practice.

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Bibliographic Details
Other Authors: Khoury, Muin J.
Format: eBook
Language:English
Published: New York ; Oxford : Oxford University Press, 2010.
Edition:2nd ed.
Subjects:
Genetic disorders > Epidemiology.
Medical genetics > Methodology.
Genomics.
Genetic screening.
Human genome.
Human genome
Genetic screening
Genomics
Online Access:Click for online access
Table of Contents:
  • Human genome epidemiology: the road map revisited
  • Principles of analysis of germline genetics
  • The public health genomics enterprise
  • Navigating the evolving knowledge of human genetic variation in health and disease
  • The global emergence of epidemiological biobanks: opportunities and challenges
  • Case-control and cohort studies in the age of genome-wide associations
  • The emergence of networks in human genome epidemiology: challenges and opportunities
  • Design and analysis issues in genome-wide association studies
  • The challenge of assessing complex gene-environment and gene-gene interactions
  • STrengthening the REporting of genetic association studies (STREGA)-an extension of the STROBE statement
  • Integration of the evidence on gene-disease associations: methods of HuGE reviews
  • Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases
  • Colorectal cancer
  • Childhood leukemias
  • Bladder cancer
  • Type 2 diabetes
  • Osteoporosis
  • Preterm birth
  • Coronary heart disease
  • Schizophrenia
  • Mendelian randomization: the contribution of genetic epidemiology to elucidating environmentally modifiable causes of disease
  • Evaluation of predictive genetic tests for common diseases: bridging epidemiological, clinical, and public health measures
  • The evaluation of genomic applications in practice and prevention (EGAPP) initiative: methods of the EGAPP working group
  • Rapid, evidence-based reviews of genetic tests
  • Role of social and behavioral research in assessing the utility of genetic information
  • Assessing the evidence for clinical utility in newborn screening
  • The role of epidemiology in assessing the potential clinical impact of pharmacogenomics
  • The human epigenome and cancer
  • The use of family history in public health practice: the epidemiologic view
  • Cytochrome P450 testing in the treatment of depression
  • A rapid-ACCE review of CYP2CP and VKORC1 allele testing to inform warfarin dosing in adults at elevated risk for thrombotic events to avoid serious bleeding
  • Hereditary hemochromatosis: population screening for gene mutations.

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