Predictive approaches in drug discovery and development : biomarkers and in vitro/in vivo correlations

Predictive approaches in drug discovery and development : biomarkers and in vitro/in vivo correlations / edited by J. Andrew Williams [and others].

Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from succ...

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Bibliographic Details
Other Authors: Williams, J. Andrew
Format: eBook
Language:English
Published: Oxford : Wiley-Blackwell, 2012.
Series:Wiley series on technologies for the pharmaceutical industry.
Subjects:
Biochemical markers.
Drug development.
Pharmaceutical technology.
MEDICAL > Drug Guides.
MEDICAL > Nursing > Pharmacology.
MEDICAL > Pharmacology.
MEDICAL > Pharmacy.
Biochemical markers
Drug development
Pharmaceutical technology
Online Access:Click for online access
Table of Contents:
  • The importance of biomarkers in translational medicine / Joseph Fleishaker
  • Fit for purpose validation of biochemical assays : challenges and solutions / Gabriella Szekely-Klepser and Scott Fountain
  • Transcriptional profiling in biomarker discovery / Michael E. Burczynski [and others]
  • Proteomic biomarker approaches in drug discovery and development / Ruth A. Vanbogelen, Jeffrey D. Thomas, and Diane Alessi
  • Application of metabolomics to pharmaceutical research and development / Qiuwei Xu and William H. Schaefer
  • Vascular biomarkers and imaging studies / Karin Potthoff, Ulrike Fiedler, and Joachim Drevs
  • Cardiovascular biomarkers as examples of success and failure in predicting safety in humans / Simon Authier [and others]
  • Use of molecular imaging for receptor occupancy decision making in drug development / R. Paul Maguire
  • Biosensors for clinical biomarkers / Sara Tombelli and Marco Mascini
  • US regulatory perspective on biomarker development / Rajnikath Madabushi, Lawrence Lesko, and Janet Woodcock
  • EU regulatory perspective on biomarkers / Ian Hudson
  • Use of biomarkers in drug development : Japanese perspectives / Yoshiaki Uyama [and others]
  • In vitro-in vivo correlations of hepatic drug clearance / R. Scott Obach
  • The potential of in silico and in vitro approaches to predict in vivo drug-drug interactions and ADMET/TOX properties / Kenneth Bachmann and Sean Ekins
  • In vitro-in vivo correlations in drug discovery and development : concepts and applications in toxicology / Rex Denton, Kimberly Brannen, and Buce D. Car
  • Assessing the potential for induction of cytochrome P450 enzymes and predicting the in vivo response / Jiunn H. Lin.

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