Pharmacokinetics in everyday clinical practice

Pharmacokinetics in everyday clinical practice / Federico Pea.

This book provides a practical introduction to the main concepts of pharmacokinetics and how they can be applied in clinical settings, without using complicated mathematical equations. Essential information on approaches to drug-dosing and monitoring in special populations, including patients with r...

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Bibliographic Details
Main Author: Pea, Federico (Author)
Format: eBook
Language:English
Published: Torino : SEEd srl., 2012.
Edition:First edition.
Subjects:
Pharmacokinetics.
Pharmacology.
pharmacology.
SCIENCE > Essays.
SCIENCE > Reference.
Pharmacokinetics
Pharmacology
Online Access:Click for online access
Table of Contents:
  • 1. Pharmacokinetics and Terminology
  • 1.1 Oral Bioavailability (Fos)
  • 1.2 Apparent Volume of Distribution (Vd)
  • 1.3 Plasma Clearance (CL)
  • 1.4 Area Under the Plasma Concentration-time Curve (AUC)
  • 1.5 Plasma Elimination Half-life (t1/2)
  • 1.6 Steady State Plasma Concentration (Css)
  • 1.7 Loading Dose (LD)
  • 1.8 Maintenance Dose (MD)
  • 2. Pharmacokinetics and Polytherapy
  • 2.1 Cytochrome P450 (CYP)
  • 2.2 P170 Glycoprotein (Pgp)
  • 3. Pharmacokinetics and Dosing Regimen
  • 4. Pharmacokinetics and Patient Pathophysiology
  • 4.1 Age
  • 4.2Renal Failure
  • 4.3 Hepatic Failure
  • 4.4 The Critically Ill Patient
  • 5. Pharmacokinetics and Pharmaceutical Technology
  • 5.1 Liposomal Formulations
  • 5.2 Controlled Release or Depot Formulations
  • 5.3 Prodrugs
  • 6. Pharmacokinetics and Pharmacogenetics
  • 6.1 Polymorphism of Phase I Enzymes
  • 6.2 Polymorphism of Phase II Enzymes
  • 7. Pharmacokinetics and Pharmacodynamics
  • 7.1 Pharmacokinetic-pharmacodynamic (PK/PD) Relationships in Antibiotic Therapy
  • 7.2 Pharmacokinetic-pharmacodynamic (PK/PD) Relationships in Antifungal Therapy
  • 8. Conclusions
  • References
  • Glossary
  • Author.

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