Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations : Principles, Methods, and Applications in the Pharmaceutical Industry

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations : Principles, Methods, and Applications in the Pharmaceutical Industry / Sheila Annie Peters.

The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceuticascience physiologicallyly-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the infor...

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Bibliographic Details
Main Author: Peters, Sheila Annie
Format: eBook
Language:English
Published: Hoboken, N.J. : Wiley, ©2011.
Subjects:
Pharmacokinetics > Mathematical models.
Drugs > Design > Mathematical models.
Pharmacokinetics.
Drugs > Design.
Biological models.
MEDICAL > Pharmacology.
Pharmacokinetics
Drugs > Design
Biological models
Pharmacokinetics > Mathematical models
Online Access:Click for online access
Table of Contents:
  • Modelling in the pharmaceutical industry
  • Physiologically-based modelling
  • A review of pharmacokinetic principles
  • Physiological model for absorption
  • Physiological model for distribution
  • Physiological models for drug metabolism and excretion
  • Generic whole-body physiologically-based pharmacokinetic modelling
  • Variability, uncertainty and sensitivity analysis
  • Evaluation of drug-drug interaction risk with pbpk models
  • PBPK of biotherapeutics
  • Data integration and sensitivity analysis
  • Hypothesis generation and pharmacokinetic predictions
  • Integration of PBPK and pharmacodynamics
  • PBPK modelling of populations
  • PBPK models along the drug discovery and development value chain.

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