Osteoblasts : morphology, functions and clinical implications

Osteoblasts : morphology, functions and clinical implications / Hugo Scheurer, editor.

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Bibliographic Details
Other Authors: Scheurer, Hugo
Format: eBook
Language:English
Published: New York : Nova Science Publishers, [2013]
Series:Cell biology research progress.
Muscular system--anatomy, functions, and injuries series.
Subjects:
Osteoclasts.
Bone resorption.
Bones > Diseases.
MEDICAL > Physiology.
SCIENCE > Life Sciences > Human Anatomy & Physiology.
Bone resorption
Bones > Diseases
Osteoclasts
Online Access:Click for online access
Table of Contents:
  • Intro
  • OSTEOBLASTS
  • OSTEOBLASTS
  • Contents
  • Preface
  • Osteoblasts under Mechanical Strain
  • Abstract
  • Abbreviations
  • 1. Introduction
  • 1.1. Bone Tissue Cellular Structure
  • 1.2. Osteoblasts
  • 1.2.1. Osteoblast Origin and Life Cycle
  • 1.2.2. Osteoblast Function
  • 1.2.3. Growth Factor and Hormone Effects on Osteoblasts
  • 1.3. Runx2 Transcription Factor in Bone Biology
  • 1.3.1. Runx2 in Osteoblast Differentiation
  • 1.3.2. Structure of Runx2 Gene
  • 1.3.3. Runx2 Expression
  • 2. Bone Remodeling
  • 2.1. Regulation of Bone Remodeling
  • 2.2. The Role of the RANK / RANKL / OPG System in Bone Remodeling
  • 2.3. Bone Remodeling Pathophysiology
  • 3. Mechanotransduction
  • 3.1. Bone Remodeling and Mechanotransduction
  • 3.2. Runx2 in Mechanotransduction
  • 3.3. Nuclear Factor Î#x9A;appa B (NF-κÎ#x92;) Transcription Factor in Mechanotransduction
  • 3.4. Polycystins in Mechanotransduction
  • 3.5. Model Systems for the Study of Mechanotransduction in Osteoblasts
  • 3.6. The Role of Mechanotransduction in Bone Disease
  • 3.7. Mechanical Stimulation as a Therapeutic Strategy against Bone Disease
  • Conclusion
  • References
  • From Stem Cells to Osteoblast: Therapeutic Potential for Bone Tissue Engineering
  • Abstract
  • Introduction
  • Mesenchymal Stem Cells
  • Differentiation of MSC into Osteoblast
  • Role of Growth Factors and Transcription Factors in Osteoblast Differentiation
  • Role of Transcription Factor in Differentiation of Osteoblast
  • Scaffolds
  • Natural Scaffolds: Extracellular Matrix
  • Glycosaminoglycans (GAGs)
  • Chitosan Scaffold
  • Tripolymer Scaffolds
  • References
  • Osteoblast Functions and their Role in Skeletal Bone Diseases
  • Abstract
  • Introduction
  • Osteoblast Lineage and Differentiation
  • Transcription Factors, Signaling Proteins and Osteoblast Differentiation
  • Osteoblast Migration
  • Osteoblasts and Bone Diseases.
  • Osteoporosis
  • Osteoarthritis
  • Osteogenesis Imperfecta
  • Van Buchem Disease and Sclerosteosis
  • Oculodentodigital Dysplasia
  • Camurati-Engelmann Disease
  • Cleidocranial Dysplaysia
  • Osteoblastic Bone Metastasis
  • Acknowledgment
  • References
  • Osteoblast Differentiation and Related Diseases
  • Abstract
  • Introduction
  • A. Transcription Factors Regulating Osteoblast Differentiation
  • RUNX2
  • TWIST1
  • MSX1 and MSX2
  • SP7/Osterix
  • β-Catenin
  • ATF4
  • FoxO1
  • B. Diseases Associated with Osteogenic Transcription Factors
  • Cleidocranial Dysplasia (CCD)
  • Saethre Chotzen Syndrome (SCS)
  • Boston-Type Craniosynostosis
  • Non-Collagenous Osteogenesis Imperfecta Caused by SP7/OSX Mutation
  • Coffin-Lowry Syndrome (CLS)
  • Neurofibromatosis Type I
  • Conclusion
  • References
  • BMP and Osteoblastogenesis Inhibitors
  • Abstract
  • Bone Morphogenetic Proteins
  • BMP-Smad Signaling
  • Extracellular Inhibitor
  • Cytomembrane Inhibitors
  • Intracellular Inhibitors
  • Nuclear Inhibitors, Which Interact with Runx2 or Osx
  • MicroRNAs
  • Prospect for Future Therapy
  • References
  • The Effect of Molecular and Biochemical Differentiation Agentson Bone Formation
  • Abstract
  • Introduction
  • Osteoblast Differentiation and Inducer Materials
  • Standard Medium for Osteogenic Cultures
  • Medium Supplements
  • Ascorbic Acid
  • 1. The Effect of Ascorobic Acid on Osteoclast Formation
  • 2. The Effect of Ascorbic Acid on Osteoblast Formation
  • B-Glycerophosphate (BGP)
  • Dexamethasone (Dex)
  • Vitamin D3
  • Bone Morphogenic Protein 2(BMP-2)
  • Collagen I and Vetronectin
  • Conclusion and Further Remarks
  • References
  • Evaluation of Characteristics of Osteoblasts and Factors Relatedto Osteoblastic Differentiation and Mineralization
  • Abstract
  • Introduction
  • Characteristics of Osteblast
  • Bone Morphogenetic Protein (BMP)
  • Various Agents.
  • Laboratory Experiments
  • (1) Cellular Proliferation
  • (2) Alkaline Phosphatase Activity Assays (ALP)
  • (3) Mineralization Assay
  • Conclusion
  • References
  • Index.

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