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Osteoblasts :
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Osteoblasts : morphology, functions and clinical implications / Hugo Scheurer, editor.
Сохранить в:
Библиографические подробности
Другие авторы:
Scheurer, Hugo
Формат:
eКнига
Язык:
English
Опубликовано:
New York :
Nova Science Publishers,
[2013]
Серии:
Cell biology research progress.
Muscular system--anatomy, functions, and injuries series.
Предметы:
Osteoclasts.
Bone resorption.
Bones
>
Diseases.
MEDICAL
>
Physiology.
SCIENCE
>
Life Sciences
>
Human Anatomy & Physiology.
Bone resorption
Bones
>
Diseases
Osteoclasts
Online-ссылка:
Click for online access
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Оглавление:
Intro
OSTEOBLASTS
OSTEOBLASTS
Contents
Preface
Osteoblasts under Mechanical Strain
Abstract
Abbreviations
1. Introduction
1.1. Bone Tissue Cellular Structure
1.2. Osteoblasts
1.2.1. Osteoblast Origin and Life Cycle
1.2.2. Osteoblast Function
1.2.3. Growth Factor and Hormone Effects on Osteoblasts
1.3. Runx2 Transcription Factor in Bone Biology
1.3.1. Runx2 in Osteoblast Differentiation
1.3.2. Structure of Runx2 Gene
1.3.3. Runx2 Expression
2. Bone Remodeling
2.1. Regulation of Bone Remodeling
2.2. The Role of the RANK / RANKL / OPG System in Bone Remodeling
2.3. Bone Remodeling Pathophysiology
3. Mechanotransduction
3.1. Bone Remodeling and Mechanotransduction
3.2. Runx2 in Mechanotransduction
3.3. Nuclear Factor Î#x9A;appa B (NF-κÎ#x92;) Transcription Factor in Mechanotransduction
3.4. Polycystins in Mechanotransduction
3.5. Model Systems for the Study of Mechanotransduction in Osteoblasts
3.6. The Role of Mechanotransduction in Bone Disease
3.7. Mechanical Stimulation as a Therapeutic Strategy against Bone Disease
Conclusion
References
From Stem Cells to Osteoblast: Therapeutic Potential for Bone Tissue Engineering
Abstract
Introduction
Mesenchymal Stem Cells
Differentiation of MSC into Osteoblast
Role of Growth Factors and Transcription Factors in Osteoblast Differentiation
Role of Transcription Factor in Differentiation of Osteoblast
Scaffolds
Natural Scaffolds: Extracellular Matrix
Glycosaminoglycans (GAGs)
Chitosan Scaffold
Tripolymer Scaffolds
References
Osteoblast Functions and their Role in Skeletal Bone Diseases
Abstract
Introduction
Osteoblast Lineage and Differentiation
Transcription Factors, Signaling Proteins and Osteoblast Differentiation
Osteoblast Migration
Osteoblasts and Bone Diseases.
Osteoporosis
Osteoarthritis
Osteogenesis Imperfecta
Van Buchem Disease and Sclerosteosis
Oculodentodigital Dysplasia
Camurati-Engelmann Disease
Cleidocranial Dysplaysia
Osteoblastic Bone Metastasis
Acknowledgment
References
Osteoblast Differentiation and Related Diseases
Abstract
Introduction
A. Transcription Factors Regulating Osteoblast Differentiation
RUNX2
TWIST1
MSX1 and MSX2
SP7/Osterix
β-Catenin
ATF4
FoxO1
B. Diseases Associated with Osteogenic Transcription Factors
Cleidocranial Dysplasia (CCD)
Saethre Chotzen Syndrome (SCS)
Boston-Type Craniosynostosis
Non-Collagenous Osteogenesis Imperfecta Caused by SP7/OSX Mutation
Coffin-Lowry Syndrome (CLS)
Neurofibromatosis Type I
Conclusion
References
BMP and Osteoblastogenesis Inhibitors
Abstract
Bone Morphogenetic Proteins
BMP-Smad Signaling
Extracellular Inhibitor
Cytomembrane Inhibitors
Intracellular Inhibitors
Nuclear Inhibitors, Which Interact with Runx2 or Osx
MicroRNAs
Prospect for Future Therapy
References
The Effect of Molecular and Biochemical Differentiation Agentson Bone Formation
Abstract
Introduction
Osteoblast Differentiation and Inducer Materials
Standard Medium for Osteogenic Cultures
Medium Supplements
Ascorbic Acid
1. The Effect of Ascorobic Acid on Osteoclast Formation
2. The Effect of Ascorbic Acid on Osteoblast Formation
B-Glycerophosphate (BGP)
Dexamethasone (Dex)
Vitamin D3
Bone Morphogenic Protein 2(BMP-2)
Collagen I and Vetronectin
Conclusion and Further Remarks
References
Evaluation of Characteristics of Osteoblasts and Factors Relatedto Osteoblastic Differentiation and Mineralization
Abstract
Introduction
Characteristics of Osteblast
Bone Morphogenetic Protein (BMP)
Various Agents.
Laboratory Experiments
(1) Cellular Proliferation
(2) Alkaline Phosphatase Activity Assays (ALP)
(3) Mineralization Assay
Conclusion
References
Index.
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