Animal models for the study of human disease

Animal models for the study of human disease / edited by P. Michael Conn.

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed informat...

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Bibliographic Details
Other Authors: Conn, P. Michael (Editor)
Format: eBook
Language:English
Published: Amsterdam : Elsevier/Academic Press, 2013.
Edition:First edition.
Subjects:
Diseases > Animal models.
Laboratory animals.
Pathology, Experimental.
MEDICAL > Laboratory Medicine.
Diseases > Animal models
Laboratory animals
Pathology, Experimental
Online Access:Click for online access
Table of Contents:
  • Front Cover; ANIMAL MODELS FOR THE STUDY OF HUMAN DISEASE; Copyright; Contents; Preface; List of Contributors; Part I -ETHICS, RESOURCES AND APPROACHES; Chapter 1
  • Ethics in Biomedical Animal Research: The Key Role of the Investigator; NATURE AND SCOPE OF THE CHAPTER; THE SUBJECT MATTER OF ANIMAL RESEARCH ETHICS; ASPECTS OF ANIMAL USE AND CARE RELEVANT TO ANIMAL RESEARCH ETHICS; WHY INVESTIGATORS ARE UNIQUELY QUALIFIED TO ENGAGE IN ETHICAL ASSESSMENT OF ANIMAL RESEARCH; WHY INVESTIGATORS SHOULD COMMIT THEMSELVES TO ETHICAL CONDUCT OF ANIMAL RESEARCH.
  • WHY INVESTIGATORS PLAY THE KEY ROLE IN ASSURING THE ETHICAL CONDUCT OF ANIMAL RESEARCH PROJECTSSOURCES OF SUPPORT AND GUIDANCE IN CONDUCTING ETHICAL RESEARCH; DEVELOPING USEFUL ETHICAL GUIDELINES; FUNDAMENTAL PRINCIPLES OF ANIMAL RESEARCH ETHICS; PRACTICAL ETHICAL GUIDELINES FOR INVESTIGATORS; SOME CURRENT DIFFICULT ISSUES IN ANIMAL RESEARCH ETHICS; GENERAL SUGGESTIONS FOR INVESTIGATORS; References; Chapter 2
  • Access to Resources: A Model Organism Database for Humans; THE PROBLEM; THE LAMHDI SOLUTION; THE IDEAL SOLUTION; Acknowledgments; References.
  • Chapter 3
  • The Advent of the Golden Era of Animal AlternativesINTRODUCTION; ANALYTICAL TOOLS FOR THE DETECTION OF FOOD-BORNE DISEASE; AN IN VITRO SYSTEM TO ASSESS ADVERSE EFFECTS DURING DEVELOPMENT; DISEASES-IN-A-DISH; NONINVASIVE IMAGING AND RECORDING; CONCLUSIONS; References; Chapter 4
  • Environmental Enrichment for Animals Used in Research; INTRODUCTION; APPLIED SCIENCE: ENRICHMENT AS A WELFARE TOOL; BASIC SCIENCE: ENRICHMENT AND ANIMAL MODELS; ENRICHMENT AND EXPERIMENTAL VARIABILITY; ENVIRONMENTAL ENRICHMENT REGULATIONS; IMPLEMENTING AN ENRICHMENT PLAN; CONCLUSIONS; Acknowledgments.
  • RETINAL DEGENERATION CAUSED BY MNU IN VARIOUS ANIMAL SPECIESAGE-RELATED PHOTORECEPTOR CELL DAMAGE AND SENSITIVITY TO MNU; PHOTORECEPTOR CELL DEATH, CELL DEBRIS REMOVAL, AND RPE CELL MIGRATION; MOLECULAR MECHANISMS IN PHOTORECEPTOR CELL DEATH CAUSED BY MNU; THERAPEUTIC TRIALS AGAINST MNU-INDUCED PHOTORECEPTOR APOPTOSIS; CONCLUDING REMARKS; Acknowledgments; References; Part III -CARDIAC AND CARDIOVASCULAR; Chapter 7
  • Animal Models of Myocardial Disease; INTRODUCTION; THE SPECTRUM OF CARDIOVASCULAR DISEASE; CHOICE OF ANIMAL SYSTEM; EXPERIMENTAL DESIGN; ISCHEMIC HEART DISEASE.

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