The Ubiquitin-Proteasome Proteolytic System : From Classical Biochemistry to Human Diseases.

The Ubiquitin-Proteasome Proteolytic System : From Classical Biochemistry to Human Diseases.

Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transp...

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Bibliographic Details
Main Author: Ciechanover, Aaron J.
Other Authors: Masucci, Maria G.
Format: eBook
Language:English
Published: Singapore : World Scientific Publishing Company, 2002.
Series:Recent advances in human biology.
Subjects:
Proteins > Metabolism.
Proteolytic enzymes.
Ubiquitin.
Enzymes.
Proteins.
Hydrolases.
Cysteine proteinases.
Multienzyme complexes.
enzyme.
protein.
Proteins
Multienzyme complexes
Hydrolases
Enzymes
Cysteine proteinases
Proteins > Metabolism
Proteolytic enzymes
Ubiquitin
Online Access:Click for online access
Table of Contents:
  • Preface ; The Ubiquitin System and Some of Its Roles in Cell Cycle Control ; References ; The Ubiquitin System and the N-End Rule Pathway ; Summary ; The Ubiquitin System ; The N-End Rule Pathway ; Physical Association of Ubiquitin Ligases and the 26S Proteasome.
  • Peptide Import and the N-End Rule Pathway The N-End Rule Pathway and Fidelity of Chromosome Segregation ; Concluding Remarks ; References ; Phosphorylation-Dependent Substrate Recognition in Ubiquitin-Mediated Proteolysis ; Abstract.
  • Modular Protein Interaction Domains Regulate Dynamic Cellular Behaviour Protein-Protein Interactions Determine Specificity in Ubiquitin-Mediated Proteolysis ; Cdk Activity and the Control of DNA Replication ; Discovery of SCF Ubiquitin Ligases.
  • Phosphorylation-Dependent Substrate Recognition by SCF Complexes Conservation of SCF Function in the Cell Cycle ; The Cdc4 Phospho-Degron ; Multi-Site Phosphorylation and Ultrasensitivity ; The Sicl-Cdc4 Interaction: Theoretical Considerations ; Discussion ; Prospects ; References.
  • The 26S Proteasome: A Supramolecular Assembly Designed for Controlled Proteolysis Introduction ; Structural Features of the 26S Proteasome ; Conclusions ; References ; Mechanisms and Regulation of Ubiquitin-Mediated Limited Processing of the NF-kBa Precursor Protein p105 ; Summary.

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