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140628s2014 xx ob 001 0 eng d |
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|a 9781118695760
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|a 1118695763
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|z 9781118349595
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|a (OCoLC)881887794
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|a QH588.S83
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|a QU325
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|a HCDD
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|a Hong, Charles C.
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|a Chemical Biology in Regenerative Medicine :
|b Bridging Stem Cells and Future Therapies.
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| 260 |
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|a Hoboken :
|b Wiley,
|c 2014.
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| 300 |
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|a 1 online resource (236 pages)
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Print version record.
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|a Chemical Biology in Regenerative Medicine; Contents; List of Contributors; Preface; 1 Wnt Signaling in Regulation of Stem Cells; 1.1 Overview of Wnt Signaling; 1.2 Wnt Signaling in Embryonic Stem Cells; 1.3 Wnt Signaling in Cardiovascular Progenitor Cells and Cardiomyocyte Differentiation; 1.4 Wnt Signaling in Mesenchymal Stem Cells; 1.5 Wnt Signaling in Hematopoiesis and Hematopoietic Stem Cells; 1.6 Wnt Signaling in Neural Stem Cells; 1.7 Wnt Signaling in Endothelial-Mesenchymal Transition; 1.8 Conclusion; References; 2 Directed Cardiomyogenesis of Pluripotent Stem Cells; 2.1 Introduction.
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|a 2.2 A Brief Review of Heart Development2.2.1 Cellular and Morphological Movements; 2.2.2 Molecular Events in Heart Development; 2.2.2.1 Molecular Events of Mesoderm Derivation; 2.2.2.2 Transcription Factors in Cardiac Development; 2.2.2.3 Major Developmental Signaling Pathways in Cardiac Development; 2.3 Introduction to Pluripotent Stem Cells; 2.3.1 Unique Features of Pluripotent Stem Cells; 2.3.2 Pluripotent Stem Cell Sources; 2.3.3 Maintaining Pluripotency; 2.4 Cardiomyocyte Differentiation; 2.4.1 Inducing Differentiation; 2.4.2 Directed Cardiomyogenesis; 2.5 Conclusion; References.
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|a 3 Chemical Genetics in Cardiomyocyte Generation3.1 Introduction; 3.2 iPSC Generation; 3.3 The Chemical Genetics Approach in iPSC Generation; 3.4 Heart Regeneration; 3.5 The Chemical Genetics Approach in Heart Regeneration; 3.6 Cardiac Cell Transdifferentiation; 3.7 Conclusion; Acknowledgements; References; 4 Challenges and New Directions for Cardiac Reprogramming; 4.1 Introduction; 4.2 Strategies for Heart Repair; 4.3 Direct Reprogramming Approaches; 4.4 Current Challenges; 4.5 Conclusion; Acknowledgements; References; 5 Comparative Analysis of Adult Stem Cell Niches; 5.1 Adult Stem Cells.
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|a 5.2 Adult Stem Cell Niches5.3 The Hair Follicle Stem Cell (HFSC) Niche; 5.4 The Intestinal Stem Cell (ISC) Niche; 5.5 The Hematopoietic Stem Cell (HSC) Niche; 5.5.1 Endosteal Niche; 5.5.2 Vascular Niche; 5.5.3 Progeny "Niche"; 5.6 The Neural Stem Cell (NSC) Niche; 5.6.1 V-SVZ Niche; 5.6.2 SGZ Niche; 5.7 A Comparison between Tissue-Specific Adult Stem Cell Niches; 5.8 Future Challenges; Acknowledgements; References; 6 Chemicals and Stem Cells in the Promotion of Regeneration; 6.1 Introduction; 6.2 Biologics in Regenerative Medicine; 6.2.1 Growth Factors and Pro-Angiogenic Agents.
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|a 6.2.2 Immune-Modulatory Therapies6.2.3 Extracellular Matrix-Based Approaches; 6.3 Chemicals and Biomaterials for Healing; 6.3.1 Small Molecules; 6.3.2 Biomaterial Scaffold and Sustained Delivery; 6.4 Stem-Cell Therapy; 6.4.1 Chemical Manipulation of Stem Cells in Regeneration; 6.4.2 Embryonic Stem Cells (ESCs); 6.4.2.1 Small Molecules for the Culture and Maintenance of ESCs; 6.4.2.2 Small Molecules for ESC Differentiation; 6.4.3 Induced Pluripotent Stem Cells (iPSCs); 6.4.3.1 Generation of iPSCs; 6.4.3.2 Small Molecules that Affect iPSC Epigenomes.
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|a 6.4.3.3 Small Molecules that Affect iPSC Signaling Pathways.
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|a Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies The field of regenerative medicine has advanced at a rapid pace and this comprehensive summary of new developments is a timely contribution to the field as clinical trials have begun to assess the safety and efficacy of cell-based therapies. In Chemical Biology in Regenerative Medicine, an international team of experts provides an overview of progress towards clinical application in the areas of transplantation (allogenic and autologous), manipulation of niche environment and.
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|a Includes bibliographical references at the end of each chapters and index.
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| 650 |
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|a Stem cells.
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| 650 |
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|a Regenerative medicine.
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| 650 |
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7 |
|a Regenerative medicine
|2 fast
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| 650 |
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7 |
|a Stem cells
|2 fast
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| 700 |
1 |
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|a Ao, Ada S.
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| 700 |
1 |
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|a Hao, Jijun.
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| 758 |
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|i has work:
|a Chemical biology in regenerative medicine (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCGPW3fcPd9vbGKDvhvQC33
|4 https://id.oclc.org/worldcat/ontology/hasWork
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| 776 |
0 |
8 |
|i Print version:
|a Hong, Charles C.
|t Chemical Biology in Regenerative Medicine : Bridging Stem Cells and Future Therapies.
|d Hoboken : Wiley, ©2014
|z 9781118349595
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| 856 |
4 |
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|u https://ebookcentral.proquest.com/lib/holycrosscollege-ebooks/detail.action?docID=1718746
|y Click for online access
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|a EBC-AC
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|a 92
|b HCD
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