Chemical Biology in Regenerative Medicine : Bridging Stem Cells and Future Therapies.

Chemical Biology in Regenerative Medicine : Bridging Stem Cells and Future Therapies.

Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies The field of regenerative medicine has advanced at a rapid pace and this comprehensive summary of new developments is a timely contribution to the field as clinical trials have begun to assess the safety and efficacy...

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Bibliographic Details
Main Author: Hong, Charles C.
Other Authors: Ao, Ada S., Hao, Jijun
Format: eBook
Language:English
Published: Hoboken : Wiley, 2014.
Subjects:
Stem cells.
Regenerative medicine.
Regenerative medicine
Stem cells
Online Access:Click for online access
Table of Contents:
  • Chemical Biology in Regenerative Medicine; Contents; List of Contributors; Preface; 1 Wnt Signaling in Regulation of Stem Cells; 1.1 Overview of Wnt Signaling; 1.2 Wnt Signaling in Embryonic Stem Cells; 1.3 Wnt Signaling in Cardiovascular Progenitor Cells and Cardiomyocyte Differentiation; 1.4 Wnt Signaling in Mesenchymal Stem Cells; 1.5 Wnt Signaling in Hematopoiesis and Hematopoietic Stem Cells; 1.6 Wnt Signaling in Neural Stem Cells; 1.7 Wnt Signaling in Endothelial-Mesenchymal Transition; 1.8 Conclusion; References; 2 Directed Cardiomyogenesis of Pluripotent Stem Cells; 2.1 Introduction.
  • 2.2 A Brief Review of Heart Development2.2.1 Cellular and Morphological Movements; 2.2.2 Molecular Events in Heart Development; 2.2.2.1 Molecular Events of Mesoderm Derivation; 2.2.2.2 Transcription Factors in Cardiac Development; 2.2.2.3 Major Developmental Signaling Pathways in Cardiac Development; 2.3 Introduction to Pluripotent Stem Cells; 2.3.1 Unique Features of Pluripotent Stem Cells; 2.3.2 Pluripotent Stem Cell Sources; 2.3.3 Maintaining Pluripotency; 2.4 Cardiomyocyte Differentiation; 2.4.1 Inducing Differentiation; 2.4.2 Directed Cardiomyogenesis; 2.5 Conclusion; References.
  • 3 Chemical Genetics in Cardiomyocyte Generation3.1 Introduction; 3.2 iPSC Generation; 3.3 The Chemical Genetics Approach in iPSC Generation; 3.4 Heart Regeneration; 3.5 The Chemical Genetics Approach in Heart Regeneration; 3.6 Cardiac Cell Transdifferentiation; 3.7 Conclusion; Acknowledgements; References; 4 Challenges and New Directions for Cardiac Reprogramming; 4.1 Introduction; 4.2 Strategies for Heart Repair; 4.3 Direct Reprogramming Approaches; 4.4 Current Challenges; 4.5 Conclusion; Acknowledgements; References; 5 Comparative Analysis of Adult Stem Cell Niches; 5.1 Adult Stem Cells.
  • 5.2 Adult Stem Cell Niches5.3 The Hair Follicle Stem Cell (HFSC) Niche; 5.4 The Intestinal Stem Cell (ISC) Niche; 5.5 The Hematopoietic Stem Cell (HSC) Niche; 5.5.1 Endosteal Niche; 5.5.2 Vascular Niche; 5.5.3 Progeny "Niche"; 5.6 The Neural Stem Cell (NSC) Niche; 5.6.1 V-SVZ Niche; 5.6.2 SGZ Niche; 5.7 A Comparison between Tissue-Specific Adult Stem Cell Niches; 5.8 Future Challenges; Acknowledgements; References; 6 Chemicals and Stem Cells in the Promotion of Regeneration; 6.1 Introduction; 6.2 Biologics in Regenerative Medicine; 6.2.1 Growth Factors and Pro-Angiogenic Agents.
  • 6.2.2 Immune-Modulatory Therapies6.2.3 Extracellular Matrix-Based Approaches; 6.3 Chemicals and Biomaterials for Healing; 6.3.1 Small Molecules; 6.3.2 Biomaterial Scaffold and Sustained Delivery; 6.4 Stem-Cell Therapy; 6.4.1 Chemical Manipulation of Stem Cells in Regeneration; 6.4.2 Embryonic Stem Cells (ESCs); 6.4.2.1 Small Molecules for the Culture and Maintenance of ESCs; 6.4.2.2 Small Molecules for ESC Differentiation; 6.4.3 Induced Pluripotent Stem Cells (iPSCs); 6.4.3.1 Generation of iPSCs; 6.4.3.2 Small Molecules that Affect iPSC Epigenomes.

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