N-Heterocyclic Carbenes : Effective Tools for Organometallic Synthesis.

N-Heterocyclic Carbenes : Effective Tools for Organometallic Synthesis.

"This comprehensive reference and handbook covers in depth all major aspects of the use of N-heterocyclic carbene-complexes in organic synthesis: from the theoretical background to characterization, and from cross-coupling reactions to olefin metathesis. Edited by a leader and experienced scien...

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Bibliographic Details
Main Author: Nolan, Steven P.
Format: eBook
Language:English
Published: Hoboken : Wiley, 2014.
Subjects:
Carbenes (Methylene compounds)
Organometallic compounds > Synthesis.
SCIENCE > Chemistry > Organic.
Organometallic compounds > Synthesis
Carbene
Stickstoffheterocyclen
Metallorganische Chemie
Online Access:Click for online access
Table of Contents:
  • Related Titles; Title Page; Copyright; Dedication; List of Contributors; Preface; Chapter 1: N-Heterocyclic Carbenes; 1.1 Introduction; 1.2 Structure and Properties of NHCs; 1.3 Abnormal Carbenes; 1.4 Why Are NHCs Stable?; 1.5 Bonding of NHCs to Metal Centers; 1.6 Quantifying the Properties of NHCs; 1.7 N-Heterocyclic Carbenes in the Context of Other Stable Carbenes; 1.8 Synthesis of NHCs; 1.9 Salts and Adducts of NHCs; 1.10 Summary; References; Chapter 2: Tuning and Quantifying Steric and Electronic Effects of N-Heterocyclic Carbenes; 2.1 Introduction; 2.2 Steric Effects in NHC ligands.
  • 2.3 Electronic Effects in NHC Ligands2.4 Conclusions; References; Chapter 3: Chiral Monodendate N-Heterocyclic Carbene Ligands in Asymmetric Catalysis; 3.1 Introduction; 3.2 NHC-Ru; 3.3 NHC-Rh; 3.4 NHC-Ir; 3.5 NHC-Ni; 3.6 NHC-Pd; 3.7 NHC-Cu; 3.8 NHC-Ag; 3.9 NHC-Au; 3.10 Conclusion; References; Chapter 4: (N-Heterocyclic Carbene)-Palladium Complexes in Catalysis; 4.1 Introduction; 4.2 Cross-Coupling Reactions; 4.3 Chelates and Pincer Ligands; 4.4 Asymmetric Catalysis; 4.5 Oxidation Reactions; 4.6 Telomerization, Oligomerization and Polymerization; 4.7 Anticancer NHC-Pd Complexes; References.
  • Chapter 5: NHC Platinum(0) Complexes: Unique Catalysts for the Hydrosilylation of Alkenes and Alkynes5.1 Introduction; 5.2 Hydrosilylation of Alkenes: The Beginning; 5.3 Initial Results with Phosphine Ligands; 5.4 NHC Platinum(0) Complexes: The Breakthrough; 5.5 Hydrosilylation of Alkynes; 5.6 Conclusions; References; Chapter 6: Synthesis and Medicinal Properties of Silver-NHC Complexes and Imidazolium Salts; 6.1 Introduction; 6.2 Silver-NHC Complexes as Antimicrobial Agents; 6.3 Silver-NHC Complexes as Anticancer Agents; 6.4 Conclusions; References.
  • Chapter 7: Medical Applications of NHC-Gold and -Copper Complexes7.1 Introduction; 7.2 Gold Antimicrobial Agents; 7.3 Metals as Antitumor Reagents; 7.4 Copper Complexes as Antitumoral Reagents; 7.5 Conclusion; References; Chapter 8: NHC-Copper Complexes and their Applications; 8.1 Introduction; 8.2 History of NHC-Copper Systems; 8.3 Hydrosilylation; 8.4 Allene Formation; 8.5 1,4-Reduction; 8.6 Conjugate Addition; 8.7 Hydrothiolation, Hydroalkoxylation, Hydroamination; 8.8 Carboxylation and Carbonylation (via Boronic Acids, CH Activation): CO2 Insertion.
  • 8.9 [3 + 2] Cycloaddition Reaction: Formation of Triazole8.10 Allylic Substitution; 8.11 Carbene and Nitrene Transfer; 8.12 Boration Reaction; 8.13 Olefination of Carbonyl Derivatives; 8.14 Copper-Mediated Cross-Coupling Reaction; 8.15 Fluoride Chemistry; 8.16 Other Reactions; 8.17 Transmetalation; 8.18 Conclusion; References; Chapter 9: NHC-Au(I) Complexes: Synthesis, Activation, and Application; 9.1 Introduction; 9.2 Synthesis of NHC-Gold(I) Chlorides; 9.3 Activation of NHC-Au(I) Chlorides; 9.4 Applications of NHC-Au(I) Catalysts; 9.5 Conclusion; References.

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