Free radicals in biology and medicine

Free radicals in biology and medicine / Barry Halliwell and John M.C. Gutteridge.

The new edition of this well-established book is thoroughly revised and gives a comprehensive account of the role of free radicals, other reactive species (RS), and antioxidants in life, health, and disease.

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Bibliographic Details
Main Authors: Halliwell, Barry (Author), Gutteridge, John M. C. (Author)
Format: eBook
Language:English
Published: Oxford : Oxford University Press, 2015.
Edition:Fifth edition.
Subjects:
Free radicals (Chemistry) > Physiological effect.
Antioxidants.
Pathology, Molecular.
Free radicals (Chemistry)
Oxidation-reduction reaction.
Oxidative stress.
antioxidant.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Oxidative stress
Oxidation-reduction reaction
Antioxidants
Free radicals (Chemistry) > Physiological effect
Pathology, Molecular
Online Access:Click for online access
Table of Contents:
  • Cover; Preface to the fifth edition; Acknowledgements; Contents; Abbreviations; Plates; 1 Oxygen: boon yet bane-introducing oxygen toxicity and reactive species; 1.1 The history of oxygen: an essential air pollutant; 1.1.1 The paradox of photosynthesis; 1.1.2 Hyperoxia in history?; 1.1.3 Oxygen in solution; 1.2 Oxygen and anaerobes; 1.2.1 Why does oxygen injure anaerobes?; 1.3 Oxygen and aerobes; 1.3.1 Oxygen transport in mammals; 1.3.2 Oxygen sensing; 1.3.3 Mitochondrial electron transport; 1.3.4 The evolution of mitochondria; 1.3.5 Nicotinamide nucleotide reduction.
  • 1.3.6 Bacterial electron transport chains1.4 Oxidases and oxygenases in aerobes; 1.4.1 Cytochromes P450; 1.5 Oxygen toxicity in aerobes; 1.5.1 Bacteria, plants, insects, and alligators; 1.5.2 Mammals; 1.5.2.1 Retinopathy of prematurity and brain damage; 1.5.2.2 Resuscitation of newborns; 1.5.2.3 Factors affecting oxygen toxicity; 1.6 What causes the toxic effects of oxygen?; 1.7 So free radicals contribute to oxygen toxicity and oxygen is one of them? What then are free radicals?; 1.8 Oxygen and its radicals; 1.8.1 Singlet oxygen; 1.8.2 Superoxide radical.
  • 1.9 How to describe them: oxygen radicals, oxygen-derived species, reactive oxygen species, or oxidants?1.10 Sources of superoxide in aerobes; 1.10.1 Enzymes; 1.10.2 Auto-oxidation reactions; 1.10.3 Haem proteins; 1.10.4 Mitochondrial electron transport; 1.10.4.1 Mitochondrial DNA (mtDNA); 1.10.5 Uncoupling proteins as antioxidants?; 1.10.6 Endoplasmic reticulum (ER); 1.10.7 Nuclear and plasma membranes; 1.10.8 Bacterial superoxide production and biofilms; 1.11 Thinking about cell culture; 1.12 Some numbers; 2 Redox chemistry: the essentials; 2.1 Introduction; 2.2 How do free radicals react?
  • 2.3 Radical chemistry: thermodynamics versus kinetics2.3.1 Redox chemistry; 2.3.1.1 Caveats; 2.3.1.2 Thermodynamics of oxygen reduction; 2.3.2 Reaction rates and rate constants; 2.3.3 Measuring reaction rates and rate constants; 2.3.3.1 Pulse radiolysis; 2.3.3.2 Stopped-flow methods; 2.4 Transition metals: biocatalytic free radicals; 2.4.1 Iron; 2.4.2 Copper; 2.4.3 Manganese; 2.4.4 The Fenton reaction; 2.4.5 Iron chelators and Fenton chemistry: speed it up or slow it down?; 2.4.6 Reaction of copper ions with H2O2; 2.5 Chemistry of other biologically important radicals; 2.5.1 Hydroxyl radical.
  • 2.5.1.1 Generation2.5.1.2 Chemistry; 2.5.2 Carbonate radical; 2.5.3 Superoxide radical; 2.5.3.1 Making superoxide in the laboratory; 2.5.3.2 Reactions of superoxide; 2.5.3.3 Superoxide-iron interactions; 2.5.3.4 Reductants and Fenton chemistry; 2.5.3.5 Semiquinones and quinones; 2.5.3.6 Superoxide in hydrophobic environments; 2.5.4 Peroxyl and alkoxyl radicals; 2.5.4.1 Chemistry; 2.5.4.2 Generation of RO2 /RO radicals; 2.5.5 Sulphur radicals; 2.5.5.1 Formation; 2.5.5.2 Reactions; 2.5.5.3 Artefacts involving sulphur compounds.

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