Therapeutic nanomaterials / edited by Mustafa O. Guler, Ayse B. Tekinay.

Addressing a cutting-edge, multidisciplinary field, this book reviews nanomaterials and their biomedical applications. It covers regeneration, implants, adhesives, and biosensors and strategies for more efficient therapy, diagnosis, and drug delivery with the use of nanotechnology. - Addresses the i...

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Bibliographic Details
Other Authors:	Güler, Mustafa Ö., 1978- (Editor), Tekinay, Ayse B. (Editor)
Format:	eBook
Language:	English
Published:	Hoboken, New Jersey : John Wiley & Sons, Inc., [2016]
Subjects:	Nanostructured materials > Therapeutic use. Medical technology. Biomedical materials. HEALTH & FITNESS > Holism. HEALTH & FITNESS > Reference. MEDICAL > Alternative Medicine. MEDICAL > Atlases. MEDICAL > Essays. MEDICAL > Family & General Practice. MEDICAL > Holistic Medicine. MEDICAL > Osteopathy. Biomedical materials Medical technology
Online Access:	Click for online access

Table of Contents:

Intro
Title Page
Copyright Page
Contents
List of Contributors
Preface
Chapter 1 Nanomaterials for Medicine
1.1 Introduction
1.2 Nanoscale Material Properties
1.3 Nanomaterials for Understanding Disease pathways
1.4 Nanomaterials for Therapy
1.5 Challenges and Future Prospects
Chapter 2 Nanosized Delivery Systems for Tissue Regeneration
2.1 Introduction
2.2 Delivery of Protein Therapeutics with Nanocarriers for Tissue Regeneration
2.2.1 Gfs and Cytokines
2.3 Gene and Sirna Delivery with Nanocarriers for Tissue Regeneration
2.3.1 Gene Delivery
2.3.2 Sirna Delivery
2.4 Systemic Targeting and Cellular Internalization Strategies for Tissue Regeneration
2.4.1 Targeted Delivery
2.4.2 Cellular Internalization Strategies
2.5 Future Perspectives
References
Chapter 3 Nanomaterials for Neural Regeneration
3.1 Introduction
3.1.1 Extracellular Matrix of Central Nervous System
3.1.2 Ecm of Peripheral Nervous System
3.1.3 Urgent Need for Materials to Induce Regeneration In nervous tissue
3.2 Nanomaterials for Neural Regeneration
3.2.1 Physical Functionalization of Nanomaterials to Induce Neural differentiation
3.2.2 Effects of Mechanical Stiffness on Cellular Behavior
3.2.3 Effects of Dimensionality on Cellular Behavior
3.2.4 Effects of Substrate Topography on Cell Behavior
3.2.5 Effects of Electrical Conductivity on Cell Behavior
3.3 Chemical and Biological Functionalization Of nanomaterials for Neural Differentiation
3.3.1 Effects of Biologically Active Molecules on Cell Behavior
3.3.2 Effects of Chemical Groups on Cellular Behavior
3.3.3 Effects of Biofunctionalization on Cellular Behavior Through ecm-derived Short Peptides
3.4 Conclusion
References
Chapter 4 Therapeutic Nanomaterials for Cartilage Regeneration
4.1 Introduction.
4.2 Current Treatment Methods for Cartilage injuries
4.3 Tissue Engineering Efforts
4.3.1 Natural Polymers
4.3.2 Synthetic Polymers
4.3.3 Composite Materials
4.3.4 Physical Stimuli
4.4 Clinical Therapeutics for Cartilage Regeneration
4.5 Conclusions and Future Perspectives
References
Chapter 5 Wound Healing Applications of Nanomaterials
5.1 Introduction
5.1.1 the Structure of Healthy Mammalian Skin
5.1.2 the Mechanisms of Wound Healing
5.1.3 Repair Process in Chronic Wounds
5.2 Applications of Nanomaterials for the Enhancement of Wound Healing Process
5.2.1 Artificial Skin
5.2.2 Natural Nanomaterials for Wound Healing
5.2.3 Synthetic Nanomaterials for Wound Healing
5.2.4 Wound Dressings Containing Growth Factors
5.2.5 Biomimetic Materials
5.2.6 Current Challenges in the Design of Nanomaterials for Chronic Wound Management
5.3 Peptide Nanofiber Gels for Wound Healing
5.3.1 Relevance of Nanofibrous Structure of Peptide Gels For wound healing
5.3.2 Engineered Pa Nanofiber Gels for Wound Healing and Insights into Various Designs
References
Chapter 6 Nanomaterials for Bone Tissue Regeneration and Orthopedic Implants
6.1 Introduction
6.2 Bone Matrix
6.2.1 Organic Matrix and Bioactivity
6.3 Inorganic Matrix, Mineralization, and Bone Organization
6.3.1 Mechanical Properties and Structural Hierarchy of Bone Tissue
6.4 Regulation of Bone Matrix in Adult Tissue
6.4.1 Angiogenic Factors in Bone Remodeling
6.5 Strategies for Bone Tissue Regeneration
6.5.1 Hard Grafts for Bone Regeneration
6.6 Soft Grafts for Bone Regeneration
6.6.1 Peptide-based Bone Grafts
6.6.2 Polymer Nanocomposites as Bone Grafts
6.7 Future Perspectives
References
Chapter 7 Nanomaterials for the Repair and Regeneration of Dental Tissues
7.1 Introduction.
7.2 Formation of Dental and Osseous Tissues
7.3 Dental Implants
7.3.1 Metallic Implants
7.3.2 Ceramic Implants
7.3.3 Polymeric Implants
7.4 Osseointegration of Dental Implants
7.5 Uses of Nanotechnology in the Development of Dental Implants
7.5.1 Enhancement of the Osseointegration Process
7.5.2 Pulp and Dentin Tissue Regeneration
7.5.3 Whole Tooth Regeneration
7.6 Conclusions and Future Perspectives
References
Chapter 8 Nanomaterials as Tissue Adhesives
8.1 Introduction
8.2 Tissue Adhesives Based on Synthetic Polymers
8.3 Naturally Derived Tissue Adhesives
8.4 Bioinspired Strategies
8.5 Nanoenabled Adhesives
8.6 Conclusion and Future Prospects
References
Chapter 9 Advances in Nanoparticle-based Medical Diagnostic And therapeutic Techniques
9.1 Introduction
9.2 Nps Used in Mri
9.2.1 T1 Cas
9.2.2 T2 Cas
9.2.3 Dual Modal Contrast Agents
9.3 Nps Used in Computed Tomography
9.3.1 Noble Metal-based Nps
9.3.2 Heavy Metal-based Nps
9.4 Nps Used in Optical and Fluorescence Imaging
9.4.1 Quantum Dots
9.4.2 Aunps
9.4.3 Ucnps
9.5 Theranostic Approaches and Multimodal systems
9.6 Overlook and Future Directions
References
Chapter 10 Biosensors for Early Disease Diagnosis
10.1 Introduction
10.2 Biosensor Elements
10.2.1 Recognition Elements
10.2.2 Output Type and Detection Techniques
10.2.3 Optical Biosensors
10.2.4 Electrical and Electrochemical Biosensors
10.2.5 Mechanical Biosensors
10.2.6 Other Biosensor Types
10.3 the Impact of Nanotechnology and Nanomaterials in Biosensor Design
10.4 Early Diagnosis and Biosensor-based Disease Detection
10.5 Conclusion and Future Directions
References
Chapter 11 Safety of Nanomaterials
11.1 Introduction
11.2 Characterization, Design, and Synthesis Of nanomaterials.
11.2.1 Chemical Identity and Physicochemical Properties
11.2.2 Biological Identity
11.3 Interactions at the Cell-material Interface
11.3.1 Intracellular Activity
11.3.2 Cellular Uptake Mechanisms
11.4 Assays for Cell Viability/proliferation
11.4.1 Assays for Oxidative Stress and Apoptosis Mechanisms
11.4.2 Evaluation of Uptake and Accumulation of Enms
11.4.3 Genotoxicity Assays
11.5 Animal Models and Long-term Risk Assessment
11.5.1 the Blood-brain Barrier
11.6 Conclusions and Future Perspectives
References
Index
EULA.

Therapeutic nanomaterials / edited by Mustafa O. Guler, Ayse B. Tekinay.

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