Mechanism of the anticancer effect of phytochemicals

Mechanism of the anticancer effect of phytochemicals / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA.

Volume 37 will provide details on the major chemical constituents of medicinal plants and their mechanism of action as the anticancer compounds. This special issue, in addition to the previous volume (volume 36 of the Enzyme series was on the topic of Natural Products and Cancer Signaling Targets: I...

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Bibliographic Details
Other Authors: Bathaie, S. Zahra (Editor), Tamanoi, Fuyuhiko (Editor)
Format: eBook
Language:English
Published: Waltham, MA : Elsevier Science, 2015.
Edition:First edition.
Series:Enzymes ; v. 37.
Subjects:
Cancer > Chemoprevention.
Cancer > Diet therapy.
Phytochemicals > Therapeutic use.
Cancer > Chemoprevention
Cancer > Diet therapy
Phytochemicals > Therapeutic use
Online Access:Click for online access
Table of Contents:
  • Front Cover; Mechanism of the Anticancer Effect of Phytochemicals; Copyright; Contents; Contributors; Preface; Chapter One: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?; 1. Introduction; 2. Phytochemicals Application in Chemoprevention Strategies; 2.1. Blocking Initiation/Reversing Promotion; 2.2. Activating Phase II Detoxifying Enzymes; 2.3. Prooxidant/Antioxidant Activities; 2.4. Protection Against Radiation; 2.5. Alteration in Signaling Pathways; 2.6. Effect on Cell-Cell Adhesion Machinery; 2.7. Induction of Epigenetic Changes.
  • 3. Phytochemicals Usage as Chemotherapeutic3.1. Inhibition of Enzymes; 3.1.1. Inhibition of Topoisomerases I or II; 3.1.2. Effect on Telomerase; 3.1.3. Other Enzymes; 3.2. Direct Binding to Biomacromolecules; 3.3. Epigenetic Alteration/Chromatin Modification; 3.3.1. Histone Modifications: Acetylation/Deacetylation and Methylation/Demethylation; 3.3.2. DNA Methylation Status; 3.4. RNA Modulation; 3.5. Autophagy and UPR68; 3.6. Apoptosis Induction; 3.7. Cell Cycle Arrest; 3.8. Inhibiting Angiogenesis; 3.9. Adjuvant/Combinatorial Therapy; 4. Summary; References.
  • Chapter Two: Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions1. Introduction; 2. Quercetin; 2.1. Source; 2.2. Biosynthesis; 2.3. Structure and Antioxidative Property; 2.4. Properties; 2.4.1. Antioxidant Property; 2.4.2. Free Radical Scavenging Activity; 2.4.3. Nitric Oxide Inhibitory Action; 2.4.4. Inhibition of Xanthine Oxidase; 2.4.5. Interaction with Other Enzyme Systems; 2.5. Pharmacokinetics; 2.6. Role as an Anticancer Agent; 2.6.1. Cell Cycle Regulation; 2.6.2. Quercetinś Effect on Apoptosis.
  • 2.6.3. Inhibition of Pathways Involved in Tumor Growth and Invasiveness2.7. Quercetinś Role as an Anti-Inflammatory Agent; 2.8. Quercetinś Influence on p53; 2.9. Quercetinś Nontoxicity Against Normal Cells; 2.10. Quercetinś Action Against Chemical-Induced Tumor and Xenograft; 2.11. Synergism with Other Drugs; 2.12. Clinical Study; 3. Tryptanthrin; 3.1. Chemistry; 3.2. Source; 3.3. Medicinal Value; 3.4. Cytotoxic and Anticancer Properties of Tryptanthrin; 3.5. Structural Modification of Tryptanthrin for Increasing its Bioactivity.
  • 3.6. Tryptanthrin Prevents Development of Cancer by the Inhibition of Various Molecular Events3.6.1. Antioxidant Activity; 3.6.2. Anti-Inflammatory Activity; 3.7. Angiogenesis; 3.8. Toxicological Analysis; 4. Conclusion; Acknowledgement; References; Chapter Three: Potential Anticancer Properties and Mechanisms of Action of Withanolides; 1. Introduction; 2. Reactive Oxygen Species Signaling; 3. Cytoskeletal Organizing and Structural Proteins; 4. Proteasomal Inhibition; 5. Inhibition of Mitosis; 6. Transcription Factors; 7. Heat Shock Proteins; 8. Metabolic Enzymes; 9. Synergistic Action.

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