Anaerobiosis and stemness : an evolutionary paradigm

Anaerobiosis and stemness : an evolutionary paradigm / Zoran Ivanovic, Marija Vlaski-Lafarge.

"Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad underst...

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Bibliographic Details
Main Authors: Ivanovic, Zoran, 1963- (Author), Vlaski-Lafarge, Marija (Author)
Format: eBook
Language:English
Published: Amsterdam : Elsevier, [2016]
Subjects:
Anaerobiosis > Therapeutic use.
Stem cells > Therapeutic use.
Stem cells.
Anaerobiosis.
Cell differentiation.
Evolution (Biology)
evolution.
SCIENCE > Life Sciences > Zoology > General.
Anaerobic bacteria
Anaerobiosis
Biotechnology > Materials
Stem cells > Research
Electronic book.
Online Access:Click for online access
Table of Contents:
  • Introduction : special remarks
  • What entity could be called a stem cell?
  • In situ Normoxia versus "hypoxia"
  • Part 1. Anaerobiosis and stem cell entity. The "hypoxic" stem cell niche
  • Low O2 concentrations and the maintenance of stem cells ex vivo
  • Quiescence/proliferation issue and stem cell niche
  • Metabolic peculiarities of the stem cell entity : energetic metabolism and oxidative status
  • Molecular basis of "hypoxic" signaling, quiescence, self-renewal, and differentiation in stem cells
  • Part 2. Anaerobic-to-aerobic eukaryote evolution : a paradigm for stem cell self-renewal, commitment and differentiation?. Evolution of eukaryotes with respect to atmosphere oxygen appearance and rise : anaerobiosis, facultative aerobiosis, and aerobiosis
  • Evolution of mitochondria in eukaryotes versus mitochondria "maturing" from the stage of stem cells to committed progenitors and mature cells
  • Evolutionary origins of stemness : relationship between self-renewal and ancestral eukaryote biology; conservation of self-renewal principle in parallel with adaptation to O2
  • Metabolic and genetic features of ancestral eukaryotes versus metabolism and "master pluripotency genes" of stem cells
  • Other features concerning the analogy "stem cells: primitive eukaryotes" : ABC transporters' anaerobiosis/stemness link
  • Harnessing anaerobic nature of stem cells for use in regenerative medicine
  • Cancer stem cell case and evolutionary paradigm.

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