The role of clinical studies for pets with naturally occurring tumors in translational cancer research : workshop summary / Sharyl J. Nass and Heather Gorby, rapporteurs ; National Cancer Policy Forum, Board on Health Care Services, Institute of Medicine.
Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models....
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