Anticancer therapeutics : from drug discovery to clinical applications

Anticancer therapeutics : from drug discovery to clinical applications / Dr. Adam A. Todd, Professor Paul W. Groundwater, Dr. Jason Gill.

An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, ph...

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Bibliographic Details
Main Authors: Todd, Adam A., 1982- (Author), Groundwater, Paul W. (Author), Gill, Jason, 1973- (Author)
Format: eBook
Language:English
Published: Hoboken, NJ : Wiley, 2017.
Edition:First edition.
Subjects:
Antineoplastic agents > Development.
Antineoplastic agents > Design.
Antineoplastic agents > Therapeutic use.
Antimitotic agents.
Antineoplastic agents.
SCIENCE > Chemistry > Industrial & Technical.
Antineoplastic agents
Antimitotic agents
Antineoplastic agents > Design
Antineoplastic agents > Development
Antineoplastic agents > Therapeutic use
Online Access:Click for online access
Table of Contents:
  • Intro
  • Title Page
  • Copyright Page
  • Contents
  • Preface
  • Section 1 Introduction
  • Chapter 1.1 The Global Burden of Cancer
  • References
  • Chapter 1.2 Cancer Staging and Classification
  • 1.2.1 Benign Tumour (or neoplasm)
  • 1.2.2 Malignant Tumour (or cancer)
  • 1.2.3 Tumour Nomenclature and Classification
  • 1.2.4 Cellular Differentiation and Tumour Grade
  • 1.2.5 Tumour Invasion and Metastasis
  • 1.2.6 Clinical Staging of Cancer
  • References
  • Chapter 1.3 Cellular and Molecular Basis of Cancer
  • 1.3.1 Oncogenes
  • 1.3.2 Tumour Suppressor Genes
  • 1.3.3 Role of Epigenetics and Gene Promoter Regulation in Tumourigenesis
  • 1.3.4 Multistage Tumourigenesis
  • 1.3.5 Oncogene Addiction
  • 1.3.6 Hallmarks of Cancer
  • 1.3.7 Principles of Cancer Treatment
  • References
  • Section 2 The Anticancer Agents
  • Chapter 2.1 Agents Which Act Directly on DNA
  • 2.1.1 Nitrogen Mustards and Nitrosoureas
  • References
  • 2.1.2 Temozolomide
  • References
  • 2.1.3 Platinum-containing agents
  • References
  • 2.1.4 Gemcitabine
  • References
  • 2.1.5 Camptothecin and Its Analogues
  • References
  • 2.1.6 Podophyllotoxins
  • References
  • 2.1.7 Anthracyclines [1]
  • References
  • 2.1.8 Epigenetic Targeting Agents [1]
  • References
  • Chapter 2.2 Antimetabolites
  • 2.2.1 Cytarabine
  • References
  • 2.2.2 Methotrexate
  • References
  • 2.2.3 5-Fluorouracil
  • References
  • 2.2.4 6-Mercaptopurine
  • References
  • Chapter 2.3 Antimicrotubule agents
  • 2.3.1 Taxanes
  • References
  • 2.3.2 Vinca Alkaloids
  • References
  • Chapter 2.4 Anti-hormonal agents
  • 2.4.1 Bicalutamide
  • References
  • 2.4.2 Tamoxifen
  • References
  • 2.4.3 Anastrozole [1]
  • References
  • Chapter 2.5 Kinase Inhibitors
  • 2.5.1 Discovery
  • 2.5.2 Synthesis
  • 2.5.3 Mode of Action
  • 2.5.4 Mechanism of Resistance [32]
  • 2.5.5 Adverse Drug Reactions
  • References
  • Section 3 The Cancers.
  • Chapter 3.1 Breast Cancer
  • 3.1.1 Epidemiology
  • 3.1.2 Presentation
  • 3.1.3 Diagnosis
  • 3.1.4 Staging
  • 3.1.5 Treatments
  • References
  • Chapter 3.2 Colorectal cancer
  • 3.2.1 Epidemiology
  • 3.2.2 Presentation
  • 3.2.3 Diagnosis
  • 3.2.4 Staging
  • 3.2.5 Treatments
  • References
  • Chapter 3.3 Leukaemia
  • 3.3.1 Epidemiology
  • 3.3.2 Presentation
  • 3.3.3 Diagnosis
  • 3.3.4 Staging
  • 3.3.5 Treatments
  • References
  • Chapter 3.4 Lung cancer
  • 3.4.1 Epidemiology
  • 3.4.2 Presentation
  • 3.4.3 Diagnosis
  • 3.4.4 Staging
  • 3.4.5 Treatments
  • References
  • Chapter 3.5 Oesophageal Cancer
  • 3.5.1 Epidemiology
  • 3.5.2 Presentation
  • 3.5.3 Diagnosis
  • 3.5.4 Staging
  • 3.5.5 Treatments
  • References
  • Chapter 3.6 Ovarian cancer
  • Key points
  • 3.6.1 Epidemiology
  • 3.6.2 Presentation
  • 3.6.3 Diagnosis
  • 3.6.4 Staging
  • 3.6.5 Treatments
  • References
  • Chapter 3.7 Pancreatic Cancer
  • 3.7.1 Epidemiology
  • 3.7.2 Presentation
  • 3.7.3 Diagnosis
  • 3.7.4 Staging
  • 3.7.5 Treatments
  • References
  • Chapter 3.8 Prostate Cancer
  • 3.8.1 Epidemiology
  • 3.8.2 Presentation
  • 3.8.3 Diagnosis
  • 3.8.4 Staging
  • 3.8.5 Treatments
  • References
  • Chapter 3.9 Skin Cancers
  • 3.9.1 Epidemiology
  • 3.9.2 Presentation
  • 3.9.3 Diagnosis
  • 3.9.4 Staging
  • 3.9.5 Treatments
  • References
  • Chapter 3.10 Testicular cancer
  • 3.10.1 Epidemiology
  • 3.10.2 Presentation
  • 3.10.3 Diagnosis
  • 3.10.4 Staging
  • 3.10.5 Treatments
  • References
  • Index
  • EULA.

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