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20240809213013.0 |
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170624s2017 xx o 000 0 eng d |
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|a 990032890
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|a 9781118952139
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|a 1118952138
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|z 1118952111
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|z 9781118952115
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|a (OCoLC)990556838
|z (OCoLC)990032890
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|a QH390
|b .K66 2017
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|a HCDD
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|a Kondrashov, Alexey S.
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|a Crumbling Genome.
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|a Somerset :
|b John Wiley & Sons, Incorporated,
|c 2017.
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| 300 |
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|a 1 online resource (294 pages)
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|a text
|b txt
|2 rdacontent
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|a computer
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|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Print version record.
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|a Title Page ; Copyright Page; Contents; Preface; Chapter 1 Genotypes and Phenotypes; 1.1 DNA is a Text; 1.2 Genomes Small and Large; 1.3 Genes and Intergenic Regions; 1.4 Cells, Mitosis, and Meiosis; 1.5 From Genotype to Phenotype; Further Reading; Chapter 2 Mendelian Inheritance and Population Genetics ; 2.1 Inheritance is Discrete; 2.2 Populations are Genetically Variable; 2.3 Loci and Genes; 2.4 Effects of Alleles on Phenotypes; 2.5 Mendelian Traits and Diseases; Further Reading; Chapter 3 Complex Traits and Their Inheritance ; 3.1 Complex Inheritance of Phenotypes.
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|a 3.2 Properties of a Complex Trait3.3 Complex Traits in Populations; 3.4 Effects of Heredity and Environment on Complex Traits; 3.5 Polymorphic Loci Behind Complex Variation; Further Reading; Chapter 4 Unavoidable Mutation ; 4.1 Phenomenon of Mutation; 4.2 Kinds of Mutations; 4.3 Spontaneous Mutation; 4.4 Evolution of Mutation Rates; 4.5 Artificial Mutagenesis and Antimutagenesis; Further Reading; Chapter 5 Struggle for Fidelity ; 5.1 Fidelity of DNA Replication; 5.2 Cleaning Up After the Replisome; 5.3 Dealing with DNA Damages; 5.4 Harms of Broken Maintenance; 5.5 Mechanisms of Mutation.
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|a Further ReadingChapter 6 Mutation Rates ; 6.1 Measuring Mutation Rates; 6.2 Data on Mutation Rates; 6.3 Guilty Older Men; 6.4 Rates of Phenotypically Drastic Mutations; 6.5 Mild Mutations and Mutational Pressures; Further Reading; Chapter 7 Natural Selection ; 7.1 Vulnerable Adaptations and Their Evolutionary Origin; 7.2 Two Basic Characteristics of Selection; 7.3 Measuring Natural Selection; 7.4 Selection at a Polymorphic Locus; 7.5 Selection on a Quantitative Trait; Further Reading; Chapter 8 Functioning DNA and Junk DNA ; 8.1 Selective Neutrality and Random Drift.
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|a 8.2 Effective Population Size8.3 Junk DNA Provides the Simplest Evidence for Evolution; 8.4 Finding Functioning Genome Segments; 8.5 The Genomic Rate of Deleterious Mutations; Further Reading; Chapter 9 It Takes All the Running You Can Do ; 9.1 Middle Class Neighborhood for Drosophila; 9.2 Selection Against Deleterious Alleles; 9.3 Mutation-Selection Equilibrium; 9.4 Inbreeding Depression; 9.5 Dangerous Slightly Deleterious Alleles; Further Reading; Chapter 10 Phenomenon of Imperfection ; 10.1 Phenotypic and Genotypic Imperfection; 10.2 Five Evolutionary Causes of Imperfection.
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|a 10.3 Weakly Perfect Human Genotypes and Phenotypes10.4 Native, Novel, and Optimal Environments; 10.5 Factors, Exacerbating Mutation Imperfection; Further Reading; Chapter 11 Our Imperfect Fitness ; 11.1 Properties of an Allele; 11.2 Human Derived Alleles; 11.3 Average Imperfection of a Genotype; 11.4 Variation Among Genotypes; 11.5 Selection in Modern Human Populations; Further Reading; Chapter 12 Our Imperfect Wellness ; 12.1 Qualitative Characteristics of Wellness; 12.2 Quantitative Traits; 12.3 Contributions of Heredity and Environment; 12.4 Wellness-impairing Alleles.
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|a 12.5 Genetic Architecture of Wellness.
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|a Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of young people suffer from diseases that are caused, exclusively or primarily, by pre-existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them.
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|a Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection.
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|a Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes.
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|a Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems.
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|a Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible.
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|a Crumbling Genome is a must-read for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society. --Book Jacket.
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| 650 |
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|a Evolutionary genetics.
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| 650 |
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|a Mutation (Biology)
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| 650 |
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7 |
|a Evolutionary genetics
|2 fast
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| 650 |
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|a Mutation (Biology)
|2 fast
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| 758 |
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|i has work:
|a Crumbling genome (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCGHc3bpRwKyk89dq4JCQD3
|4 https://id.oclc.org/worldcat/ontology/hasWork
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| 776 |
0 |
8 |
|i Print version:
|a Kondrashov, Alexey S.
|t Crumbling Genome.
|d Somerset : John Wiley & Sons, Incorporated, ©2017
|z 9781118952115
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| 856 |
4 |
0 |
|u https://ebookcentral.proquest.com/lib/holycrosscollege-ebooks/detail.action?docID=4875207
|y Click for online access
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|a EBC-AC
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|b HCD
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