Crumbling Genome.

Crumbling Genome.

Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human g...

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Bibliographic Details
Main Author: Kondrashov, Alexey S.
Format: eBook
Language:English
Published: Somerset : John Wiley & Sons, Incorporated, 2017.
Subjects:
Evolutionary genetics.
Mutation (Biology)
Evolutionary genetics
Online Access:Click for online access
Table of Contents:
  • Title Page ; Copyright Page; Contents; Preface; Chapter 1 Genotypes and Phenotypes; 1.1 DNA is a Text; 1.2 Genomes Small and Large; 1.3 Genes and Intergenic Regions; 1.4 Cells, Mitosis, and Meiosis; 1.5 From Genotype to Phenotype; Further Reading; Chapter 2 Mendelian Inheritance and Population Genetics ; 2.1 Inheritance is Discrete; 2.2 Populations are Genetically Variable; 2.3 Loci and Genes; 2.4 Effects of Alleles on Phenotypes; 2.5 Mendelian Traits and Diseases; Further Reading; Chapter 3 Complex Traits and Their Inheritance ; 3.1 Complex Inheritance of Phenotypes.
  • 3.2 Properties of a Complex Trait3.3 Complex Traits in Populations; 3.4 Effects of Heredity and Environment on Complex Traits; 3.5 Polymorphic Loci Behind Complex Variation; Further Reading; Chapter 4 Unavoidable Mutation ; 4.1 Phenomenon of Mutation; 4.2 Kinds of Mutations; 4.3 Spontaneous Mutation; 4.4 Evolution of Mutation Rates; 4.5 Artificial Mutagenesis and Antimutagenesis; Further Reading; Chapter 5 Struggle for Fidelity ; 5.1 Fidelity of DNA Replication; 5.2 Cleaning Up After the Replisome; 5.3 Dealing with DNA Damages; 5.4 Harms of Broken Maintenance; 5.5 Mechanisms of Mutation.
  • Further ReadingChapter 6 Mutation Rates ; 6.1 Measuring Mutation Rates; 6.2 Data on Mutation Rates; 6.3 Guilty Older Men; 6.4 Rates of Phenotypically Drastic Mutations; 6.5 Mild Mutations and Mutational Pressures; Further Reading; Chapter 7 Natural Selection ; 7.1 Vulnerable Adaptations and Their Evolutionary Origin; 7.2 Two Basic Characteristics of Selection; 7.3 Measuring Natural Selection; 7.4 Selection at a Polymorphic Locus; 7.5 Selection on a Quantitative Trait; Further Reading; Chapter 8 Functioning DNA and Junk DNA ; 8.1 Selective Neutrality and Random Drift.
  • 8.2 Effective Population Size8.3 Junk DNA Provides the Simplest Evidence for Evolution; 8.4 Finding Functioning Genome Segments; 8.5 The Genomic Rate of Deleterious Mutations; Further Reading; Chapter 9 It Takes All the Running You Can Do ; 9.1 Middle Class Neighborhood for Drosophila; 9.2 Selection Against Deleterious Alleles; 9.3 Mutation-Selection Equilibrium; 9.4 Inbreeding Depression; 9.5 Dangerous Slightly Deleterious Alleles; Further Reading; Chapter 10 Phenomenon of Imperfection ; 10.1 Phenotypic and Genotypic Imperfection; 10.2 Five Evolutionary Causes of Imperfection.
  • 10.3 Weakly Perfect Human Genotypes and Phenotypes10.4 Native, Novel, and Optimal Environments; 10.5 Factors, Exacerbating Mutation Imperfection; Further Reading; Chapter 11 Our Imperfect Fitness ; 11.1 Properties of an Allele; 11.2 Human Derived Alleles; 11.3 Average Imperfection of a Genotype; 11.4 Variation Among Genotypes; 11.5 Selection in Modern Human Populations; Further Reading; Chapter 12 Our Imperfect Wellness ; 12.1 Qualitative Characteristics of Wellness; 12.2 Quantitative Traits; 12.3 Contributions of Heredity and Environment; 12.4 Wellness-impairing Alleles.

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