The rewiring brain : a computational approach to structural plasticity in the adult brain

The rewiring brain : a computational approach to structural plasticity in the adult brain / edited by Arjen van Ooyen, VU University Amsterdam, Amsterdam, the Netherlands, Markus Butz-Ostendorf, Biomax Informatics AG, Planegg, Germany.

The adult brain is not as hard-wired as traditionally thought. By modifying their small- or large-scale morphology, neurons can make new synaptic connections or break existing ones (structural plasticity). Structural changes accompany memory formation and learning, and are induced by neurogenesis, n...

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Bibliographic Details
Other Authors: Van Ooyen, Arjen (Editor), Butz-Ostendorf, Markus (Editor)
Format: eBook
Language:English
Published: London ; San Diego, CA : Academic Press, 2017.
Subjects:
Brain > Physiology.
Cognitive neuroscience.
Neuroplasticity.
Computer simulation.
Digital computer simulation.
simulation.
MEDICAL > Physiology.
SCIENCE > Life Sciences > Human Anatomy & Physiology.
SCIENCE > Life Sciences > Neuroscience.
Digital computer simulation
Computer simulation
Brain > Physiology
Cognitive neuroscience
Neuroplasticity
Online Access:Click for online access
Table of Contents:
  • Front Cover; The Rewiring Brain; Copyright Page; Contents; List of Contributors; Editorial; 1 Introduction; 2 Experimental Background; 3 Homeostatic Structural Plasticity; 4 Structural Plasticity and Connectivity; 5 Structural Plasticity and Learning and Memory; 6 Neurogenesis-Related Structural Plasticity; 7 Structural Plasticity and Pathology; 8 Outlook; References; I. Experimental Background; 1 Structural Plasticity and Cortical Connectivity; 1 Introduction; 2 The Role of Structural Synaptic Plasticity in Hebb's Theory of Cell Assemblies.
  • 3 Structural Plasticity Following Enriched Experience4 Structural Plasticity Following Sensory Deprivation or Stimulation; 5 Structural Plasticity in Learning and Memory; 6 Structural Plasticity and Long-Term Functional Synaptic Plasticity; 7 Activity-Dependent and -Independent Structural Synaptic Plasticity; 8 Structural Plasticity and Cortical Connectivity; 8.1 Large-Scale Structural Plasticity; 8.2 Microscopic Structural Plasticity and Cortical Connectivity; 8.3 Mechanisms of Microscopic Structural Plasticity Influencing Cortical Connectivity; 9 Future Perspectives; Acknowledgments.
  • 4 Dendritic Arbor Remodeling5 Dendritic Spine Plasticity; 6 Perspectives and Future Directions; 6.1 Technological Developments; 6.2 Minimizing the Dark Side of Structural Plasticity Through Intelligent Intervention; 6.3 Computational Modeling Studies; References; 4 Is Lesion-Induced Synaptic Rewiring Driven by Activity Homeostasis?; 1 Introduction; 2 Current View and Limitations; 2.1 Current View; 2.2 Limitations; 3 Homeostatic Structural Plasticity; 3.1 Hypothesis; 3.2 Expectations; 4 In Vitro Indications for Homeostatic Structural Plasticity; 4.1 Dendritic Spines.
  • 4.2 Dendrite and Axon Outgrowth4.3 Minimum Activity for Spine Formation and Neurite Outgrowth; 5 In Vivo Indications for Homeostatic Structural Plasticity; 5.1 Visual Cortex; 5.2 Barrel Cortex; 5.3 Stroke; 6 Experimental Testing of Homeostatic Structural Plasticity; 6.1 Growth Curves; 6.2 Activity Restoration; 7 Discussion; 7.1 Relation to Other Forms of Plasticity; 7.2 Cortical Remapping; 7.3 Maladaptive Responses; 7.4 Neurodegeneration; 7.5 Neurological Therapy; 7.6 Computational Modeling; 8 Conclusion; References; II. Homeostatic Structural Plasticity.

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