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Continuous biomanufacturing :
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Continuous biomanufacturing : innovative technologies and methods / edited by Ganapathy Subramanian.
Saved in:
Bibliographic Details
Other Authors:
Subramanian, G., 1935-
(Editor)
Format:
eBook
Language:
English
Published:
Weinheim :
Wiley-VCH,
[2018]
Subjects:
Pharmaceutical biotechnology.
Biopharmaceutics.
Biochemical engineering.
Biologicals.
MEDICAL
>
Pharmacology.
Biochemical engineering
Biopharmaceutics
Pharmaceutical biotechnology
Online Access:
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Table of Contents
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Table of Contents:
Continuous Biomanufacturing: Innovative Technologies and Methods; Contents; List of Contributors; Part One: Overview of State-of-the-Art Technologies and Challenges; Chapter 1: Continuous Bioprocess Development: Methods for Control and Characterization of the Biological System; 1.1 Proposed Advantages of Continuous Bioprocessing; 1.1.1 Introduction; 1.2 Special Challenges for Continuous Bioprocesses; 1.2.1 The Biological System in Continuous Biomanufacturing; 1.2.2 Inherent Changes in the Microbial System
Problem of Evolution; 1.2.3 Lack of Process Information.
1.2.3.1 Models-Based Process Development and Control for Continuous Processes1.2.3.2 Engineering Approach to Complex Systems; 1.2.4 Limited Control Strategies; 1.2.4.1 Traditional Control Strategies for Continuous Cultures; 1.3 Changes Required to Integrate Continuous Processes in Biotech; 1.3.1 A Better Physiological Understanding of the Organisms and Their Responses on the Reactor Environment; 1.3.1.1 Model Complexity; 1.3.1.2 Models; 1.3.2 Model-Based Process Monitoring; 1.3.3 Implementation of Model Predictive Control; 1.3.3.1 Model-Based Control.
1.4 Role of Iterative Process Development to Push Continuous Processes in Biotech1.4.1 Methods for Development of Continuous Processes; 1.4.1.1 Alternative: Fed-Batch as a System to Simulate Quasi Steady-State Conditions; 1.4.2 Mimicking Industrial Scale Conditions in the Lab: Continuous-Like Experiments; 1.4.2.1 A Simple Model for Continuous Processes; 1.4.2.2 Continuous-Like Fed-Batch Cultivations; 1.4.3 Fast and Parallel Experimental Approaches with High Information Content; 1.4.3.1 Computer-Aided Operation of Robotic Facilities; 1.4.3.2 Model Building and Experimental Validation.
1.5 ConclusionsReferences; Chapter 2: Tools Enabling Continuous and Integrated Upstream and Downstream Processes in the Manufacturing of Biologicals; 2.1 Introduction; 2.2 Continuous Upstream Processes; 2.2.1 Continuous Bioprocesses: With or Without Cell Recycle?; 2.2.2 Early/Scale-Down Perfusion Development; 2.2.3 Feeding and Operational Strategies in Perfusion Processes; 2.2.4 Cell Retention Devices; 2.3 Continuous Downstream Processes; 2.3.1 Continuous Liquid Chromatography (CLC); 2.3.1.1 Continuous Annular Chromatography (CAC).
2.3.1.2 True and Simulated Moving Bed Chromatography (TMB/SMB)2.3.1.3 Multicolumn Countercurrent Solvent Gradient Purification (MCSGP); 2.3.1.4 Periodic Countercurrent Chromatography (PCC); 2.3.1.5 Continuous Countercurrent Tangential Chromatography (CCTC); 2.3.2 Nonchromatographic Continuous Processes; 2.3.2.1 Continuous Aqueous Two-Phase Systems; 2.3.2.2 Continuous Protein Precipitation; 2.3.3 Straight-Through Processes; 2.3.4 Continuous Virus Clearance Processes; 2.4 Integrated Continuous Processes; 2.5 Concluding Remarks; References.
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