Molecular Pathology : the Molecular Basis of Human Disease.

Molecular Pathology : the Molecular Basis of Human Disease.

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Bibliographic Details
Main Author: Coleman, William B.
Other Authors: Tsongalis, Gregory J.
Format: eBook
Language:English
Published: Saint Louis : Elsevier Science, 2017.
Edition:2nd ed.
Subjects:
Pathology, Molecular.
Molecular biology.
molecular biology.
Molecular biology
Pathology, Molecular
Online Access:Click for online access
Table of Contents:
  • Front Cover
  • MOLECULAR PATHOLOGY
  • MOLECULAR PATHOLOGY: THE MOLECULAR BASIS OF HUMAN DISEASE
  • Dedication
  • List of Contributors
  • Preface
  • 1
  • Molecular Mechanisms of Cell Death
  • INTRODUCTION
  • MODES OF CELL DEATH
  • STRUCTURAL FEATURES OF NECROSIS AND APOPTOSIS
  • Oncotic Necrosis
  • Apoptosis
  • CELLULAR AND MOLECULAR MECHANISMS UNDERLYING NECROTIC CELL DEATH
  • Metastable State Preceding Necrotic Cell Death
  • Mitochondrial Dysfunction and ATP Depletion
  • Mitochondrial Uncoupling in Necrotic Cell Killing
  • Mitochondrial Permeability TransitionInner Membrane Permeability
  • Mitochondrial Permeability Transition Pore
  • pH-dependent Ischemia/Reperfusion Injury
  • Role of the Mitochondrial Permeability Transition in pH-Dependent Reperfusion Injury
  • Oxidative Stress
  • Protein Kinase Signaling and the MPT
  • Other Stress Mechanisms Inducing Necrotic Cell Death
  • Poly (ADP-Ribose) Polymerase
  • Plasma Membrane Injury
  • PATHWAYS TO APOPTOSIS
  • Roles of Apoptosis in Biology
  • Plasma Membrane
  • MITOCHONDRIA
  • Cytochrome c Release
  • Regulation of the Mitochondrial Pathway to ApoptosisAntiapoptotic Survival Pathways
  • NUCLEUS
  • ENDOPLASMIC RETICULUM
  • LYSOSOMES
  • SHARED PATHWAYS TO NECROSIS AND APOPTOSIS
  • PROGRAMMED NECROSIS
  • Ferroptosis
  • Pyroptosis
  • Necroptosis
  • CONCLUDING REMARK
  • Acknowledgments
  • References
  • 2
  • Acute and Chronic Inflammation Induces Disease Pathogenesis
  • INTRODUCTION
  • LEUKOCYTE ADHESION, MIGRATION, AND ACTIVATION
  • Endothelial Cell Expression of Adhesion Molecules
  • Chemoattractants
  • ACUTE INFLAMMATION AND DISEASE PATHOGENESIS
  • PATTERN RECOGNITION RECEPTORS AND INFLAMMATORY RESPONSESToll-Like Receptors
  • Cytoplasmic Sensors of Pathogens
  • Pattern Recognition and Pathologic Consequences
  • Innate Lymphoid Cells
  • Regulation of Acute Inflammatory Responses
  • CHRONIC INFLAMMATION AND ACQUIRED IMMUNE RESPONSES
  • T-Lymphocyte Regulation of Chronic Inflammation
  • B-Lymphocyte and Antibody Responses
  • Exacerbation of Chronic Diseases
  • TISSUE REMODELING DURING ACUTE AND CHRONIC INFLAMMATORY DISEASE
  • Profibrogenic Cytokines and Growth Factors Involved in Fibrotic Tissue Remodeling
  • TGFβTNFα
  • References
  • 3
  • Infection and Host Response
  • INTRODUCTION
  • MICROBES AND HOSTSâ#x80;#x94;BALANCE OF POWER? [1]
  • THE STRUCTURE OF THE IMMUNE RESPONSE [2â#x80;#x93;4]
  • REGULATION OF IMMUNITY [4]
  • PATHOGEN STRATEGIES
  • STAPHYLOCOCCUS AUREUS: THE EXTRACELLULARâ#x80;B̄ATTLEGROUND
  • The Innate Immune System: Recognition of Pathogens
  • Inhibition of Inflammatory Cell Recruitment and Phagocytosis [7â#x80;#x93;9]
  • Inhibition of Complement Activation: You Canâ#x80;#x99;t Tag Me! [10]
  • Inactivation of Antimicrobial Mechanisms [9,11]

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