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on1027203147 |
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OCoLC |
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20241006213017.0 |
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m o d |
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180303s2018 nju o 000 0 eng d |
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|a EBLCP
|b eng
|e pn
|c EBLCP
|d OCLCQ
|d DEBBG
|d OCLCQ
|d REDDC
|d OCLCF
|d K6U
|d OCLCQ
|d OCLCO
|d SXB
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|a 9783527688081
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|a 3527688080
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|a (OCoLC)1027203147
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|a TA164
|b .S968 2018
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|a HCDD
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| 100 |
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|a Lee, Sang Yup.
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| 245 |
1 |
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|a Synthetic Biology :
|b Parts, Devices and Applications.
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| 260 |
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|a Newark :
|b John Wiley & Sons, Incorporated,
|c 2018.
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| 300 |
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|a 1 online resource (428 pages)
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Advanced Biotechnology Ser.
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|a Print version record.
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|a Cover; Title Page; Copyright; Contents; About the Series Editors; Part I DNA Synthesis and Genome Engineering; Chapter 1 Competition and the Future of Reading and Writing DNA; 1.1 Productivity Improvements in Biological Technologies; 1.2 The Origin of Mooreâ#x80;#x99;s Law and Its Implications for Biological Technologies; 1.3 Lessons from Other Technologies; 1.4 Pricing Improvements in Biological Technologies; 1.5 Prospects for New Assembly Technologies; 1.6 Beyond Programming Genetic Instruction Sets; 1.7 Future Prospects; References.
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|a Chapter 2 Trackable Multiplex Recombineering (TRMR) and Next-Generation Genome Design Technologies: Modifying Gene Expression in E. coli by Inserting Synthetic DNA Cassettes and Molecular Barcodes2.1 Introduction; 2.2 Current Recombineering Techniques; 2.2.1 Recombineering Systems; 2.2.2 Current Model of Recombination; 2.3 Trackable Multiplex Recombineering; 2.3.1 TRMR and T2RMR Library Design and Construction; 2.3.2 Experimental Procedure; 2.3.3 Analysis of Results; 2.4 Current Challenges; 2.4.1 TRMR and T2RMR are Currently Not Recursive; 2.4.2 Need for More Predictable Models.
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|a 2.5 Complementing Technologies2.5.1 MAGE; 2.5.2 CREATE; 2.6 Conclusions; Definitions; References; Chapter 3 Site-Directed Genome Modification with Engineered Zinc Finger Proteins; 3.1 Introduction to Zinc Finger DNA-Binding Domains and Cellular Repair Mechanisms; 3.1.2 Homologous Recombination; 3.1.3 Non-homologous End Joining; 3.2 Approaches for Engineering or Acquiring Zinc Finger Proteins; 3.2.1 Modular Assembly; 3.2.2 OPEN and CoDA Selection Systems; 3.2.3 Purchase via Commercial Avenues; 3.3 Genome Modification with Zinc Finger Nucleases.
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|a 3.4 Validating Zinc Finger Nuclease-Induced Genome Alteration and Specificity3.5 Methods for Delivering Engineered Zinc Finger Nucleases into Cells; 3.6 Zinc Finger Fusions to Transposases and Recombinases; 3.7 Conclusions; References; Chapter 4 Rational Efforts to Streamline the Escherichia coli Genome; 4.1 Introduction; 4.2 The Concept of a Streamlined Chassis; 4.3 The E. coli Genome; 4.4 Random versus Targeted Streamlining; 4.5 Selecting Deletion Targets; 4.5.1 General Considerations; 4.5.1.1 Naturally Evolved Minimal Genomes; 4.5.1.2 Gene Essentiality Studies.
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|a 4.5.1.3 Comparative Genomics4.5.1.4 In silico Models; 4.5.1.5 Architectural Studies; 4.5.2 Primary Deletion Targets; 4.5.2.1 Prophages; 4.5.2.2 Insertion Sequences (ISs); 4.5.2.3 Defense Systems; 4.5.2.4 Genes of Unknown and Exotic Functions; 4.5.2.5 Repeat Sequences; 4.5.2.6 Virulence Factors and Surface Structures; 4.5.2.7 Genetic Diversity-Generating Factors; 4.5.2.8 Redundant and Overlapping Functions; 4.6 Targeted Deletion Techniques; 4.6.1 General Considerations; 4.6.2 Basic Methods and Strategies; 4.6.2.1 Circular DNA-Based Method; 4.6.2.2 Linear DNA-Based Method.
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| 500 |
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|a 4.6.2.3 Strategy for Piling Deletions.
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| 650 |
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0 |
|a Synthetic biology.
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| 650 |
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7 |
|a Synthetic biology
|2 fast
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| 700 |
1 |
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|a Nielsen, Jens.
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| 700 |
1 |
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|a Stephanopoulos, Gregory.
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| 700 |
1 |
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|a Smolke, Christina.
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| 776 |
0 |
8 |
|i Print version:
|a Lee, Sang Yup.
|t Synthetic Biology : Parts, Devices and Applications.
|d Newark : John Wiley & Sons, Incorporated, ©2018
|z 9783527330751
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| 830 |
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0 |
|a Advanced Biotechnology Ser.
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| 856 |
4 |
0 |
|u https://ebookcentral.proquest.com/lib/holycrosscollege-ebooks/detail.action?docID=5309272
|y Click for online access
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| 903 |
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|a EBC-AC
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| 994 |
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|a 92
|b HCD
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