Handbook of brain tumor chemotherapy, molecular therapeutics, and immunotherapy

Handbook of brain tumor chemotherapy, molecular therapeutics, and immunotherapy / edited by Herbert B. Newton, MD, FAAN.

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first editio...

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Bibliographic Details
Other Authors: Newton, Herbert B. (Editor)
Format: eBook
Language:English
Published: London ; San Diego, CA : Academic Press, an imprint of Elsevier, [2018]
Edition:Second edition.
Subjects:
Brain > Tumors > Chemotherapy > Handbooks, manuals, etc.
Molecular genetics > Handbooks, manuals, etc.
Molecular biology > Handbooks, manuals, etc.
Immunotherapy > Handbooks, manuals, etc.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
MEDICAL > Chemotherapy.
MEDICAL > Oncology.
Immunotherapy
Molecular biology
Molecular genetics
handbooks.
Handbooks and manuals
Handbooks and manuals.
Guides et manuels.
Online Access:Click for online access
Table of Contents:
  • Front Cover; Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy; Copyright; Contents; Contributors; Section I: Pharmacological and Clinical Applications; Chapter 1: Overview of Brain Tumor Epidemiology and Histopathology; Epidemiology of Brain Tumors; Pathology of Central Nervous System Tumors-Introduction; Pathology of Tumors of Neuroepithelial Origin; Pathology of Tumors of the Meninges; Pathology of Primary CNS Lymphoma; Pathology of Intracranial Germ Cell Tumors; References; Chapter 2: Clinical Pharmacology of Brain Tumor Chemotherapy; Introduction
  • Pharmacology and Drug DistributionSupportive Therapeutics; Corticosteroids; Gastric Acid Inhibitors; Anticonvulsants; Delivery of Chemotherapeutic Agents; Continuous Infusion; Intra-Arterial; Interstitial; Blood-Brain Barrier Disruption; Chemotherapeutic Agents; Alkylating Agents; Nitrogen Mustards; Nitrosoureas; Procarbazine; Platinum Compounds; Temozolomide; Natural Products; Vinca Alkaloids; Pyrimidine Analogs; Purine Analogs; Folic Acid Analogs; Topoisomerase Inhibitors; Camptothecin Derivatives; Conclusions; References
  • Chapter 3: Antiepileptic Drugs and Chemotherapy: Potential Interactions and Impact on Treatment of Patients With CancerIntroduction; Mechanism of Interaction Between AEDs and CTAs; Phase I Interactions; Phase II Interactions; Other Potential Mechanisms of AED/CTA Interactions; The Impact of AED-CTA Interactions; EIAED Effects on Targeted Therapies; AED Selection in Cancer Patients; Expected Enzyme Induction Profile of New AEDs; Changing From One AED to Another; Conclusions; Disclosure; References; Chapter 4: Brain Tumor Models for Cancer Therapy; Rat Brain Tumor Models
  • Blood-Brain Barrier in Rat Brain Tumor ModelsLocal Delivery in Rat Brain Tumor Models; Immunological Approaches in Rat Brain Tumor Models; Chemotherapy and Boron Neutron Capture in Rat Brain Tumor Models; Human Brain Tumor Xenograft Models; Blood-Brain Barrier in Human Brain Tumor Xenograft Models; Local Delivery in Human Brain Tumor Xenograft Models; Chemotherapy in Human Brain Tumor Xenograft Models; Angiogenesis in Brain Tumor Models; References; Chapter 5: Genomics and Proteomics in Neuro-Oncology; Introduction; RNA Expression Analysis; DNA Methylation Analysis; Disease Proteomics
  • Preanalytic and Bioinformatic ConsiderationsTumor Expression Profiling: Medulloblastoma; Molecular Basis and Genomic Subclassification of Medulloblastomas; Tumor Expression Profiling: Glioma; Drug Discovery and Targeting; Summary; References; Further Reading; Chapter 6: Chemotherapy Resistance; Common Chemotherapeutic Agents in Gliomas; DNA Repair and Chemotherapy Resistance; Methylguanine Methyltransferase; Histone Modification; MicroRNAs and Long Noncoding RNAs; DNA Mismatch Repair; Nucleotide and Base Excision Repair; Detoxification and Other Mechanisms of Resistance

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