Molecular Technology : Life Innovation.

Molecular Technology : Life Innovation.

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Bibliographic Details
Main Author: Yamamoto, Hisashi
Other Authors: Kato, Takashi
Format: eBook
Language:English
Published: Newark : John Wiley & Sons, Incorporated, 2018.
Subjects:
Biotechnology.
Nanotechnology > Research.
bioengineering.
Biotechnology
Nanotechnology > Research
Online Access:Click for online access
Table of Contents:
  • Cover; Title Page; Copyright; Contents; Foreword by Dr Hamaguchi; Foreword by Dr Noyori; Preface; Chapter 1 Control of DNA Packaging by Block Catiomers for Systemic Gene Delivery System; 1.1 Introduction; 1.2 Packaging of pDNA by Block Catiomers; 1.2.1 Rod-Shaped Packaging of pDNA; 1.2.2 Rod Shape or Globular Shape; 1.3 Polyplex Micelles as a Systemic Gene Delivery System; 1.3.1 Stable Encapsulation of pDNA Within Polyplex Micelles for Systemic Delivery; 1.3.2 Polyplex Micelles for Efficient Cellular Entry; 1.3.3 Polyplex Micelles for Safe Endosome Escape.
  • 1.3.4 Polyplex Micelles for Nuclear Translocation1.3.5 Polyplex Micelles for Efficient Transcription; 1.4 Design Criteria of Block Catiomers Toward Systemic Gene Therapy; 1.5 Rod Shape or Toroid Shape; 1.6 Summary; References; Chapter 2 Manipulation of Molecular Architecture with DNA; 2.1 Introduction; 2.2 Molecular Structure of DNA; 2.3 Immobile DNA Junctions; 2.4 Topologically Unique DNA Molecules; 2.5 DNA Tiles and Their Assemblies; 2.6 DNA Origami; 2.7 DNA Origami as a Molecular Peg Board; 2.8 Molecular Machines Made of DNA Origami; 2.9 DNA Origami Pinching Devices.
  • 2.10 Novel Design Principles2.11 DNA-PAINT: An Application of DNA Devices; 2.12 Prospects; References; Chapter 3 Chemical Assembly Lines for Skeletally Diverse Indole Alkaloids; 3.1 Introduction; 3.2 Macmillan's Collective Total Synthesis by Means of Organocascade Catalysis; 3.3 Systematic Synthesis of Indole Alkaloids Employing Cyclopentene Intermediates by the Zhu Group; 3.4 Biogenetically Inspired Synthesis Employing a Multipotent Intermediate by the Oguri Group; References; Chapter 4 Molecular Technology for Injured Brain Regeneration; 4.1 Introduction; 4.2 Biology of Angiogenesis.
  • 4.3 Angiogenesis for Injured Brain Regeneration4.4 Molecular Technology to Promote Angiogenesis; 4.5 Biology of Cell Cycle; 4.6 Biology of Neurogenesis; 4.7 Molecular Technology to Promote Neuron Regeneration; 4.8 Conclusion; References; Chapter 5 Engineering the Ribosomal Translation System to Introduce Non-proteinogenic Amino Acids into Peptides; 5.1 Introduction; 5.2 Decoding the Genetic Code; 5.3 Aminoacylation of tRNA by Aminoacyl-tRNA Synthetases; 5.4 Methods for Preparing Noncanonical Aminoacyl-tRNAs; 5.4.1 Ligation of Aminoacyl-pdCpA Dinucleotide with tRNA Lacking the 32 Terminal CA.
  • 5.4.2 Post-aminoacylation Modification of Aminoacyl-tRNA5.4.3 Misacylation of Non-proteinogenic Amino Acids by ARSs; 5.4.4 Flexizyme, an Aminoacylation Ribozyme; 5.5 Methods for Assigning Non-proteinogenic Amino Acids to the Genetic Code; 5.5.1 The Nonsense Codon Method; 5.5.2 Genetic Code Reprogramming; 5.5.3 The Four-base Codon Method; 5.5.4 The Nonstandard Base Method; 5.6 Limitation of the Incorporation of Noncanonical Amino Acids: Substrate Scope; 5.7 Improvement of the Substrate Tolerance of Ribosomal Translation.

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