Chemical engineering in the pharmaceutical industry : active pharmaceutical ingredients

Chemical engineering in the pharmaceutical industry : active pharmaceutical ingredients / edited by David J. Am Ende, Mary T. Am Ende.

A guide to the development and manufacturing of pharmaceutical products written for professionals in the industry, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry is a practical book that highlights chemistry and chemical engineeri...

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Bibliographic Details
Other Authors: Ende, David J. am (Editor), Ende, Mary T. am (Editor)
Format: eBook
Language:English
Published: Hoboken, NJ : John Wiley & Sons, [2019]
Edition:Second edition.
Subjects:
Pharmaceutical technology.
Biochemical engineering.
Chemical engineering.
chemical engineering.
MEDICAL > Pharmacology.
Biochemical engineering
Chemical engineering
Pharmaceutical technology
Online Access:Click for online access
Table of Contents:
  • Intro; TITLE PAGE; COPYRIGHT PAGE; CONTENTS; LIST OF CONTRIBUTORS; PREFACE; UNIT CONVERSIONS; PART 1 INTRODUCTION; CHAPTER 1 CHEMICAL ENGINEERING IN THE PHARMACEUTICAL INDUSTRY: AN INTRODUCTION; 1.1 GLOBAL IMPACT OF THE INDUSTRY; 1.2 INVESTMENTS IN PHARMACEUTICAL R 1.3 BEST SELLERS; 1.4 PHARMACEUTICAL RESEARCH AND DEVELOPMENT EXPENDITURES; 1.5 RECENT TRENDS FOR PHARMACEUTICAL DRUG AND MANUFACTURING; 1.6 CHEMICAL ENGINEERS SKILLED TO IMPACT FUTURE OF PHARMACEUTICAL INDUSTRY; REFERENCES; CHAPTER 2 CURRENT CHALLENGES AND OPPORTUNITIES IN THE PHARMACEUTICAL INDUSTRY; 2.1 INTRODUCTION
  • 2.2 INDUSTRY-WIDE CHALLENGES2.3 OPPORTUNITIES FOR CHEMICAL ENGINEERS; 2.4 PROSPECTS FOR CHEMICAL ENGINEERS; REFERENCES; PART II MASS AND ENERGY BALANCES; CHAPTER 3 PROCESS SAFETY AND REACTION HAZARD ASSESSMENT; 3.1 INTRODUCTION; 3.2 GENERAL CONCEPTS; 3.3 STUDYING THE DESIRED SYNTHESIS REACTION AT LAB SCALE; 3.4 SCALE-UP OF THE DESIRED REACTION; 3.5 STUDYING THE DECOMPOSITION REACTION AT LAB SCALE; 3.6 REACTIVE WASTE; 3.7 CONTINUOUS PROCESSING; 3.8 OTHER POINTS TO CONSIDER; REFERENCES; CHAPTER 4 CALORIMETRIC APPROACHES TO CHARACTERIZING UNDESIRED REACTIONS; 4.1 INTRODUCTION; 4.2 BACKGROUND
  • 4.3 THERMAL STABILITY SCREENING: DIFFERENTIAL SCANNING CALORIMETRY (DSC)4.4 PRESSURE SCREENING OF DECOMPOSITIONS: TECHNIQUES; 4.5 HAZARD SCENARIOS; 4.6 CASE STUDY 1: REACTION IN DIMETHYL SULFOXIDE (DMSO); 4.7 CASE STUDY 2: CONTINUOUS GAS GENERATION IN A WASTE STREAM CONTAINING CARBONATE; 4.8 CASE STUDY 3: EVALUATING A FUNCTIONAL GROUP; 4.9 CASE STUDY 4: USE OF THERMAL AND PRESSURE SCREENING TOOLS TO ASSESS AN mCPBA SOLUTION; 4.10 NOTATIONS; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 5 CASE STUDY OF A BORANE-THF EXPLOSION; 5.1 INTRODUCTION; 5.2 BACKGROUND; 5.3 INVESTIGATION
  • 5.4 ARC DATA OF BTHF FROM AN ADJACENT CYLINDER5.5 TEMPERATURE HISTORY OF THE BORANE-THF CYLINDERS; 5.6 HEAT LOSS MEASUREMENTS; 5.7 THERMAL STABILITY OF FRESH 2M BORANE-THF; 5.8 KINETICS OF DECOMPOSITION; 5.9 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 6 ANALYTICAL ASPECTS FOR DETERMINATION OF MASS BALANCES; 6.1 INTRODUCTION; 6.2 THE USE OF ANALYTICAL METHODS APPLIED TO ENGINEERING; 6.3 METHODS USED AND BACKGROUND; 6.4 THINGS TO WATCH OUT FOR IN LC AND GC; 6.5 USE OF MULTIPLE ANALYTICAL TECHNIQUES; 6.6 CONCLUSION; REFERENCES; CHAPTER 7 QUANTITATIVE APPLICATIONS OF NMR SPECTROSCOPY
  • 7.1 INTRODUCTION7.2 ONE-DIMENSIONAL NMR METHODS; 7.3 TWO-DIMENSIONAL NMR METHODS; 7.4 QUANTITATIVE NMR SPECTROSCOPY (qNMR); REFERENCES; PART III REACTION KINETICS AND MIXING PROCESSES; CHAPTER 8 REACTION KINETICS AND CHARACTERIZATION; 8.1 INTRODUCTION; 8.2 FUNDAMENTALS OF CHEMICAL REACTION KINETICS; 8.3 METHODS FOR THE CHARACTERIZATION OF CHEMICAL KINETICS; 8.4 TRANSFORMING EXPERIMENTAL DATA INTO A KINETIC MODEL; 8.5 EMERGING AREAS FOR INNOVATION AND IMPLEMENTATION; 8.6 CONCLUSIONS; 8.7 QUESTIONS; REFERENCES; CHAPTER 9 UNDERSTANDING FUNDAMENTAL PROCESSES IN CATALYTIC HYDROGENATION REACTIONS

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