Chemical Engineering in the Pharmaceutical Industry, R & d to Manufacturing

Chemical Engineering in the Pharmaceutical Industry, R & d to Manufacturing

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Bibliographic Details
Main Author: Am Ende, David J.
Other Authors: Am Ende, Mary Tanya
Format: eBook
Language:English
Published: Newark : John Wiley & Sons, Incorporated, 2019.
Edition:2nd ed.
Subjects:
Biochemical engineering.
Chemical engineering.
Pharmaceutical technology.
chemical engineering.
Biochemical engineering
Chemical engineering
Pharmaceutical technology
Online Access:Click for online access
Table of Contents:
  • Intro; TITLE PAGE; COPYRIGHT PAGE; CONTENTS; LIST OF CONTRIBUTORS; PREFACE; UNIT CONVERSIONS; PART I INTRODUCTION; CHAPTER 1 CHEMICAL ENGINEERING IN THE PHARMACEUTICAL INDUSTRY; 1.1 GLOBAL IMPACT OF THE INDUSTRY; 1.2 INVESTMENTS IN PHARMACEUTICAL R 1.3 BEST SELLERS; 1.4 PHARMACEUTICAL RESEARCH AND DEVELOPMENT EXPENDITURES; 1.5 RECENT TRENDS FOR PHARMACEUTICAL DRUG AND MANUFACTURING; 1.6 CHEMICAL ENGINEERS SKILLED TO IMPACT FUTURE OF PHARMACEUTICAL INDUSTRY; REFERENCES; PART II DRUG PRODUCT DESIGN, DEVELOPMENT, AND MODELING; CHAPTER 2 DESIGN OF SOLID DOSAGE FORMULATIONS; 2.1 INTRODUCTION
  • 2.2 UNDERSTANDING DRUG SUBSTANCE2.3 EXCIPIENTS; 2.4 DRUG-EXCIPIENT COMPATIBILITY STUDY; 2.5 PROCESSING OF FORMULATIONS; 2.6 TABLET FORMULATION DESIGN; 2.7 TABLET CHARACTERISTICS; 2.8 USING DISSOLUTION TO DETERMINE CQAs; 2.9 DRUG PRODUCT STABILITY; 2.10 PROCESS OPERATIONS AND SCALABILITY OF DOSAGE FORM; 2.11 CONCLUDING REMARKS; REFERENCES; CHAPTER 3 POWDER PROCESS CHALLENGES AND SOLUTIONS; 3.1 INTRODUCTION; 3.2 COMMON POWDER-HANDLING EQUIPMENT; 3.3 POWDER FLOW AND SEGREGATION CONCERNS; 3.4 MEASUREMENT OF FLOW PROPERTIES
  • 3.5 TROUBLE-SHOOTING POWDER-HANDLING PROBLEMS AND EQUIPMENT DESIGN METHODSREFERENCES; CHAPTER 4 DESIGN AND SCALE-UP OF DRY GRANULATION PROCESSES; 4.1 OVERVIEW OF THE DRY GRANULATION PROCESS; 4.2 GENERAL CONSIDERATIONS FOR ROLLER COMPACTION OPERATIONS AND EQUIPMENT; 4.3 MATERIAL BEHAVIOR, QUALITY ATTRIBUTES, AND TESTING; 4.4 PRINCIPLES OF OPERATION; 4.5 SCALE-UP OF ROLLER COMPACTION; 4.6 SUMMARY; REFERENCES; CHAPTER 5 MODEL-BASED DEVELOPMENT OF ROLLER COMPACTION PROCESSES; 5.1 INTRODUCTION; 5.2 ROLL COMPACTION; 5.3 MILLING
  • 5.4 PROPERTY FUNCTIONS FOR MODEL-BASED DEVELOPMENT OF ROLLER COMPACTION5.5 CONNECTING PROCESS AND PROPERTY MODELS; 5.6 SUMMARY; 5.7 NOTATION; REFERENCES; CHAPTER 6 WET GRANULATION PROCESSES; 6.1 INTRODUCTION; 6.2 MECHANISMS IN WET GRANULATION; 6.3 SCALE-UP; 6.4 FUTURE DIRECTIONS; REFERENCES; CHAPTER 7 TOWARD A GENERIC MODEL FOR TWIN-SCREW WET GRANULATION; 7.1 INTRODUCTION; 7.2 EXPERIMENTAL DATA COLLECTION; 7.3 GRANULE SIZE DISTRIBUTIONS AT DIFFERENT LOCATIONS; 7.4 PBM MODEL DEVELOPMENT; 7.5 PBM MODEL CALIBRATION; 7.6 RESULTS FOR THE WETTING ZONE 1; 7.7 RESULTS FOR THE FIRST KNEADING ZONE 3
  • 7.8 RESULTS FOR THE SECOND KNEADING ZONE 67.9 RESULTS OF DIRECT SIMULATION FROM PREBLEND TO FINAL GRANULES AT TSG OUTLET (ZONES 1-6); 7.10 OUTLOOK; REFERENCES; CHAPTER 8 MODELING A DOSATOR CAPSULE FILLING PROCESS FOR HARD-SHELL CAPSULES; 8.1 OVERVIEW OF THE DOSATOR CAPSULE FILLING PROCESS; 8.2 DEM MODEL OF THE DOSATOR PROCESS; 8.3 MODELING RESULTS FOR THE DOSATOR FILLING PROCESS; 8.4 CASE STUDY: PREDICTION OF OPTIMAL INSERTION DEPTH INTO THE POWDER BED DURING A DOSATOR FILLING PROCESS; 8.5 SUMMARY; REFERENCES; CHAPTER 9 POWDER COMPACTION; 9.1 INTRODUCTION

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