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|a Personalized and precision medicine informatics :
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|b Springer,
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|a Health informatics
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|a Birth of a discipline: personalized and precision medicine (PPM) informatics -- Clinical risk assessment and prediction -- Principles of guideline-driven PPM informatics -- Genetic counseling at the intersection of clinical genetics and informatics -- Fundamentals of drug metabolism and pharmacogenomics within a learning healthcare system workflow perspective -- The growing medication problem: perspective from industry -- Risk stratification and prognosis using predictive modelling and big data approaches -- Informatics methods for molecular profiling -- Constructing software for cancer research in support of molecular PPM -- Platform-independent gene-expression based classification-system for molecular sub-typing of cancer -- Tumor sequencing: enabling personalized targeted treatments with informatics -- Largescale distributed PPM databases: harmonizing and standardizing PPM cohorts and clinical genomics data sharing consortia -- Redefining disease using informatics -- Pragmatic trials and new informatics methods to supplement or replace phase IV trials -- Precision trials informatics -- Informatics for a precision learning healthcare system -- The genomic medical record and omic ancillary systems -- Generalizable architectures and principles of informatics for scalable personalized and precision medicine (PPM) decision support -- Building comprehensive enterprise-scale PPM clinical informatics capability and capacity -- Personalized and precision medicine informatics education -- The landscape of PPM informatics and the future of medicine.
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| 504 |
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|a Includes bibliographical references and index.
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| 520 |
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|a This book adopts an integrated and workflow-based treatment of the field of personalized and precision medicine (PPM). Outlined within are established, proven and mature workflows as well as emerging and highly-promising opportunities for development. Each workflow is reviewed in terms of its operation and how they are enabled by a multitude of informatics methods and infrastructures. The book goes on to describe which parts are crucial to discovery and which are essential to delivery and how each of these interface and feed into one-another. Personalized and Precision Medicine Informatics provides a comprehensive review of the integrative as well as interpretive nature of the topic and brings together a large body of literature to define the topic and ensure that this is the key reference for the topic. It is an unique contribution that is positioned to be an essential guide for both PPM experts and non-experts, and for both informatics and non-informatics professionals.
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|a Online resource; title from PDF title page (ProQuest Ebook Central, viewed February 12, 2021).
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|a Medical informatics.
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|a Biomedical engineering.
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|a Adam, Terrence,
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|a Aliferis, Constantin F.,
|e editor.
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|t Personalized and Precision Medicine Informatics : A Workflow-Based View.
|d Cham : Springer, ©2019
|z 9783030186258
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