Thyroid and heart : a comprehensive translational essay

Thyroid and heart : a comprehensive translational essay / Giorgio Iervasi, Alessandro Pingitore, A. Martin Gerdes, Salman Razvi, editors.

In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies - including multicenter studies - have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an upd...

Full description

Saved in:
Bibliographic Details
Other Authors: Iervasi, Giorgio, Pingitore, Alessandro, Gerdes, A. Martin, Razvi, Salman
Format: eBook
Language:English
Published: Cham : Springer, 2020.
Edition:Second edition.
Subjects:
Heart > Diseases > Etiology.
Hyperthyroidism > Complications.
Endocrinology.
General practice.
Public health & preventive medicine.
Cardiovascular medicine.
Medical > Endocrinology & Metabolism.
Medical > Family & General Practice.
Medical > Public Health.
Medical > Cardiology.
Heart > Diseases > Etiology
Electronic books.
Online Access:Click for online access
Table of Contents:
  • Intro
  • Foreword
  • Foreword: Thyroid and the Heart: A Roadmap
  • Preface
  • Contents
  • Part I: Heart and Thyroid: Historical and Basic Aspects
  • 1: Thyroid and the Heart: A Historical Perspective
  • 1.1 Heart Thyrotoxicosis
  • 1.2 Myxedema Heart
  • References
  • 2: Physiological Role of Thyroid Hormone in the Developing and Mature Heart
  • 2.1 Introduction
  • 2.2 Membrane Transport
  • 2.3 Metabolism
  • 2.4 Effect of Thyroid Hormone in Heart Development
  • 2.5 Effect of Thyroid Hormone in the Mature Heart
  • 2.6 Conclusions
  • References
  • 3: Thyroid Hormone Signaling Mechanisms in the Heart and Vasculature
  • 3.1 TH Signaling Through Nuclear TRs
  • 3.2 TR Isoforms
  • 3.3 Cellular Localization of TRs
  • 3.4 Posttranslational Modification of TRs
  • 3.5 Genes Regulated by THs
  • 3.5.1 Cardiomyocyte Calcium Transients and Contractility
  • 3.5.2 Transverse-Tubules
  • 3.5.3 Metabolism and Mitochondria
  • 3.6 TH Signaling Through Cytosolic TRs
  • 3.7 Vascular Responses to TH
  • 3.7.1 Angiogenesis and Vascular Remodeling
  • 3.8 TH Effects Independent of TRs
  • 3.8.1 TH Activation of Ion Channels
  • 3.9 Conclusions
  • 5: Diastolic and Systolic Dysfunction of the Heart and Thyroid Hormone Abnormalities
  • 5.1 Mechanism of Action of Thyroid Hormone on Myocardium
  • 5.2 Hyperthyroidism and Cardiac Dysfunction
  • 5.3 Effects of Overt Hypothyroidism on Cardiac Function
  • 5.4 Action of Subclinical Hypothyroidism
  • 5.4.1 Cardiac Function at Rest and During Exercise in Subclinical Hypothyroidism
  • 5.4.2 Peripheral Vascular Abnormalities in Subclinical Hypothyroidism
  • 5.5 Action of Low T3 Syndrome
  • 5.6 Beneficial Effects of Thyroid Hormone Treatment
  • References
  • Part III: Thyroid System in CV Diseases in Experimental Models
  • 6: TH Metabolism in Ischemia/Reperfusion Models
  • 6.1 Introduction
  • 6.2 Overview of Thyroid Hormones and Receptors
  • 6.3 Thyroid Hormone Metabolism
  • 6.3.1 Deiodination Pathways
  • 6.3.2 Alternative Pathways
  • 6.4 Effect of TH Dysfunction on CVD and Vice Versa
  • 6.5 Cardioprotection by TH in Ischemia: A Lesson From Experimental Models
  • 6.6 Conclusions
  • References
  • 7: Thyroid Hormone Deiodinative Pathways in the Normal and Failing Heart
  • 7.1 Introduction

Similar Items