PET and SPECT of neurobiological systems

PET and SPECT of neurobiological systems / Rudi A.J.O. Dierckx, Andreas Otte, Erik F.J. de Vries, Aren van Waarde, editors ; Adriaan A. Lammertsma, guest editor.

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Bibliographic Details
Other Authors: Dierckx, Rudi A. J. O., Otte, Andreas P., 1967-, Vries, Erik F. J. de, Waarde, Aren van, Lammertsma, Adriaan A.
Format: eBook
Language:English
Published: Cham, Switzerland : Springer, [2021]
Edition:2nd ed.
Subjects:
Tomography, Emission.
Radioisotope scanning.
Tomography, Emission
Radioisotope scanning
Online Access:Click for online access
Table of Contents:
  • Intro
  • Foreword
  • Preface
  • Contents
  • Part I: Basics
  • 1: Animal Models for Brain Research
  • 1.1 Introduction to Animal Modelling for Human Brain Disease
  • 1.1.1 Relevance of Animal Models
  • 1.1.2 Validity of Animal Models
  • 1.1.2.1 Face Validity
  • 1.1.2.2 Construct Validity
  • 1.1.2.3 Aetiological Validity
  • 1.1.2.4 Predictive Validity
  • 1.1.3 Homology, Analogy and Isomorphism
  • 1.1.4 Generalisation and Extrapolation
  • 1.2 Animal Models of Psychiatric Disorders
  • 1.2.1 The Endophenotype Concept in Psychiatry
  • 1.2.2 Approaches to Modelling Psychiatric Disease
  • 1.2.2.1 Behavioural Approach
  • 1.2.2.2 Pharmacological Models
  • 1.2.2.3 Genetic Models
  • 1.2.3 Animal Models of Schizophrenia
  • 1.2.3.1 Aetiology and Symptomatology of Schizophrenia
  • 1.2.3.2 Validating Animal Models of Schizophrenia
  • Electrophysiological Endophenotypes
  • Cognitive Endophenotypes
  • Locomotor Activity
  • Sensory Discrimination
  • Negative Symptoms
  • 1.2.3.3 Neurodevelopmental Schizophrenia Models
  • 1.2.3.4 Drug-Induced Schizophrenia Models
  • Psychostimulant Models
  • Hallucinogen Models
  • 1.2.3.5 Lesion-Induced Schizophrenia Models
  • 1.2.3.6 Genetic Schizophrenia Models
  • Inbred and Selectively Bred Rodent Strains
  • Genetically Modified Models
  • 1.3 Animal Models of Neurological Disorders
  • 1.3.1 Approaches to Modelling Neurological Disorders
  • 1.3.2 Animal Models of Alzheimer's Disease
  • 1.3.2.1 Aetiology and Symptomatology of Alzheimer's Disease
  • 1.3.2.2 Validating Animal Models of Alzheimer's Disease
  • Cognitive Symptoms
  • BPSD-Related Symptoms
  • Pathological Alterations
  • Neurochemical Alterations
  • 1.3.2.3 Spontaneous and Selectively Bred Alzheimer's Disease Models
  • 2.1.3.1 Volume of Distribution
  • 2.1.3.2 Input Function
  • 2.1.3.3 One-Tissue Compartment Model
  • 2.1.3.4 Two-Tissue Compartment Model
  • 2.1.3.5 Logan Plot
  • 2.1.4 Reference Tissue Models
  • 2.1.4.1 Binding Potential
  • 2.1.4.2 Simplified Reference Tissue Model
  • 2.1.5 Receptor Occupancy and Displacement
  • 2.1.6 Semiquantitative Approach
  • 2.1.7 Radioligands
  • 2.2 PET Motion Correction: State of the Art
  • 2.2.1 The Need for Awake PET: Anesthesia, Stress, and Its Impact on Small Animal PET
  • 2.2.2 Motion Correction in PET Reconstruction

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