Phase I Oncology Drug Development

Phase I Oncology Drug Development / Timothy A. Yap, Jordi Rodon, David S. Hong, editors.

This book provides a detailed review of how oncology drug development has changed over the past decade, and serves as a comprehensive guide for the practicalities in setting up phase I trials. The book covers strategies to accelerate the development of novel antitumor compounds from the laboratory t...

Full description

Saved in:
Bibliographic Details
Other Authors: Yap, Timothy A. (Editor), Rodon, Jordi (Editor), Hong, David S. (Editor)
Format: eBook
Language:English
Published: Cham : Springer, 2020.
Subjects:
Antineoplastic agents > Design.
Cancer > Chemotherapy.
Drug development.
Medicine.
Oncology.
Radiotherapy.
medicines (material)
medicine (discipline)
Medical > Radiology & Nuclear Medicine.
Medical > Oncology.
Medicine
Drug development
Cancer > Chemotherapy
Antineoplastic agents > Design
Oncology
Radiotherapy
Electronic books.
Online Access:Click for online access
Table of Contents:
  • Paradigm shift in oncology drug development
  • Practicalities in setting up phase I trials
  • Optimizing the preclinical development of antitumor agents for entry into phase I trials
  • Considerations for the development of novel chemotherapies in phase I trials
  • Considerations for the development of novel targeted agents in phase I trials
  • Development of immunotherapeutic strategies in early phase clinical trials
  • Assessment of radiotherapeutic strategies in phase I trials
  • Development of combinatorial strategies in phase I trials
  • Novel trial designs for early phase clinical trials
  • Incorporating pharmacokinetic strategies for phase I trials
  • Development of pharmacodynamic biomarkers for phase I trials
  • Efficacy considerations for Phase I trials
  • Incorporating precision medicine into Phase I clinical trials
  • Molecular profiling of patients for clinical trials
  • Incorporating circulating biomarkers into clinical trials
  • Statistical considerations for early phase clinical trials
  • Lessons from hematology for solid tumor drug development.

Similar Items