Histone deacetylase inhibitors in combinatorial anticancer therapy

Histone deacetylase inhibitors in combinatorial anticancer therapy / Shabir Ahmad Ganai.

This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC) inhibitors in the context of potential cancer therapy. HDAC inhibitors are emerging as promising anticancer drug molecules that promote growth arrest, differentiation a...

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Bibliographic Details
Main Author: Ganai, Shabir Ahmad (Author)
Format: eBook
Language:English
Published: Singapore : Springer, [2020]
Subjects:
Histone deacetylase > Inhibitors.
Cancer > Treatment.
Cancer > Research.
Gene expression.
Medical genetics.
Nucleic acids.
Cancer > Treatment
Cancer > Research
Gene expression
Medical genetics
Nucleic acids
Online Access:Click for online access
Table of Contents:
  • Chapter 1_Epigenetic modifying enzymes.-Chapter 2_Epigenetic modifying enzymes implicated in cancer.-Chapter 3_Classification of histone deacetylases (HDACs).-Chapter 4_Implications of 18 HDAC isoforms in therapeutically monotonous cancers.-Chapter 5_Possible Mechanisms of HDACs in Cancer development
  • Chapter 6_Different strategies employed for circumventing cancer resistance (chemo and radio) and mitigating toxicity.-Chapter 7_Limitations of conventional therapeutic regimens in treating cancer.-Chapter 8_Overview of epidrugs with special emphasis on HDAC inhibitors (HDACi)
  • Chapter 9_HDAC inhibitors as promising epidrugs for treating cancer.-Chapter 10_ HDAC inhibitors in anticancer monotherapy.-Chapter 11_Distinct groups of histone deacetylase inhibitors (HDACi) based on the structural distinction, HDACs targeted.-Chapter 12_Limited efficacy of HDAC inhibitor-based monotherapy.-Chapter 13_Resistance mechanisms generated by cancer cells against HDACi based monotherapy.-Chapter 14_ Toxicity issue of HDAC inhibitor based monotherapy.-Chapter 15_Combinatorial therapeutic strategies of HDACi.-Chapter 16_Designing Selective HDACi using computational and medicinal chemistry approach.-Chapter 17. Current therapeutic challenges and future directions.

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