Reactive oxygen species : network pharmacology and therapeutic applications

Reactive oxygen species : network pharmacology and therapeutic applications / Harald H.H.W. Schmidt, Pietro Ghezzi, Antonio Cuadrado, editors.

Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neuro...

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Bibliographic Details
Other Authors: Schmidt, Harald H. H. W. (Editor), Ghezzi, P. (Pietro) (Editor), Cuadrado, Antonio (Editor)
Format: eBook
Language:English
Published: Cham : Springer, [2021]
Series:Handbook of experimental pharmacology ; v. 264.
Subjects:
Active oxygen > Physiological effect.
Oxidative stress.
Active oxygen > Physiological effect
Oxidative stress
Online Access:Click for online access
Table of Contents:
  • Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine
  • Demystifying oxidative stress
  • Oxidants in Physiological Processes
  • Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies
  • Part II Targeting antioxidant responses
  • Development of Telintra as an Inhibitor of Glutathione S-Transferase P
  • Perspectives on the Clinical Development of NRF2-Targeting Drugs
  • Part III: Inhibiting ROS formation and toxification
  • NOX Inhibitors: From Bench to Naxibs to Bedside
  • Nitric Oxide Synthase Inhibitors into the Clinic at Last
  • Xanthine Oxidoreductase Inhibitors
  • Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches
  • Inhibition of Myeloperoxidase
  • Part IV: Stimulating/substituting ROS
  • Effects of Mammalian Thioredoxin Reductase Inhibitors
  • Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO" and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation
  • Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers
  • Part V: Repairing ROS damage
  • Soluble Guanylate Cyclase Stimulators and Activators
  • Peter Sander
  • Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.

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