Hereditary breast and ovarian cancer : molecular mechanism and clinical practice

Hereditary breast and ovarian cancer : molecular mechanism and clinical practice / Seigo Nakamura, Daisuke Aoki, Yoshio Miki, editors.

This highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and vari...

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Bibliographic Details
Other Authors: Nakamura, Seigo (Editor), Aoki, Daisuke (Editor), Miki, Yoshio (Editor)
Format: eBook
Language:English
Published: Singapore : Springer, 2021.
Subjects:
Breast > Cancer > Genetic aspects.
Breast > Cancer > Molecular aspects.
Ovaries > Cancer > Genetic aspects.
Ovaries > Cancer > Molecular aspects.
Breast > Cancer > Genetic aspects
Breast > Cancer > Molecular aspects
Ovaries > Cancer > Genetic aspects
Ovaries > Cancer > Molecular aspects
Càncer d'ovari.
Càncer de mama.
Genètica molecular humana.
Electronic books.
Llibres electrònics.
Online Access:Click for online access
Table of Contents:
  • 1 History, Advancements, and Future Strategies
  • 2 Molecular basis of BRCA1 and BRCA2
  • Homologous recombination deficiency and tissue-specific carcinogenesis
  • 3 Genetic Testing
  • 4 Variants of uncertain significances in hereditary breast and ovarian cancer
  • 5 Genetic counseling in Hereditary Breast and Ovarian Cancer
  • 6 Hereditary Breast Cancer
  • 7 Hereditary Ovarian Cancer
  • 8 Risk-Based Breast Cancer Screening
  • 9 Chemoprevention for Breast Cancer
  • 10 Chemoprevention for Ovarian Cancer
  • 11 Risk-Reducing Mastectomy (RRM)
  • 12 Risk-reducing salpingo-oophorectomy (RRSO)
  • 13 Panel Testing
  • 14 Germline Findings through Precision Oncology for Ovarian Cancer
  • 15 Germline Findings from Genetic Testing for Breast Cancer
  • 16 Hereditary Breast and Ovarian Cancer (HBOC) Database
  • 17 Ethical Issues: Overview in Genomic analysis and Clinical Context
  • 18 PARP Inhibitors-Mechanism of action
  • 19 PARPi
  • Efficacy in Hereditary Breast Cancer
  • 20 Efficacy of Poly ADP-Ribose Polymerase Inhibitors for Hereditary Ovarian Cancer.

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