Pharmacology of the WNT signaling system

Pharmacology of the WNT signaling system / Gunnar Schulte, Pawel Kozielewicz, editors.

This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of...

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Bibliographic Details
Other Authors: Schulte, Gunnar (Editor), Kozielewicz, Pawel (Editor)
Format: eBook
Language:English
Published: Cham : Springer, [2021]
Series:Handbook of experimental pharmacology ; v. 269.
Subjects:
Wnt pathway.
Wnt proteins.
Neuropharmacology.
Neuropharmacology
Wnt pathway
Wnt proteins
Farmacologia.
Electronic books.
Llibres electrònics.
Online Access:Click for online access
Table of Contents:
  • Pharmacological thinking in WNT signaling
  • Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically
  • WNTs on exosomes
  • Strategies to target LRPs in WNT signaling
  • Targeting the receptor tyrosine kinase ROR1 by small molecules
  • Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors
  • Disheveled proteins as crucial mediators of WNT signaling
  • Destruction complex and regulation of CTNNB1
  • Strategies to therapeutically target WNT/PCP like signaling in disease
  • Mining natural compounds to target WNT signaling
  • from mushrooms to corals
  • FZD7 as a therapeutic target in intestinal cancer
  • Targeting oncogenic WNT signaling with WNT derived peptides
  • Targeting WNT signaling in lung pathology
  • The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting
  • WNT signaling in Alzheimers disease and other neurodegenerative disorders
  • opportunities for therapy?
  • Targeting WNT signaling as a risk.

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